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Randomized Controlled Trial
. 2010 Nov;54(11):4910-3.
doi: 10.1128/AAC.00725-10. Epub 2010 Aug 16.

Low frequency of intermittent HIV-1 semen excretion in patients treated with darunavir-ritonavir at 600/100 milligrams twice a day plus two nucleoside reverse transcriptase inhibitors or monotherapy

Sidonie Lambert-Niclot  1 , Gilles Peytavin, Claudine Duvivier, Catherine Poirot, Michèle Algarte-Genin, Sophie Pakianather, Jean-Luc Meynard, Marc-Antoine Valantin, Jean-Michel Molina, Philippe Flandre, Christine Katlama, Vincent Calvez, Anne-Geneviève Marcelin
Affiliations
Randomized Controlled Trial

Low frequency of intermittent HIV-1 semen excretion in patients treated with darunavir-ritonavir at 600/100 milligrams twice a day plus two nucleoside reverse transcriptase inhibitors or monotherapy

Sidonie Lambert-Niclot et al. Antimicrob Agents Chemother. 2010 Nov.

Abstract

HIV-1 RNA level and darunavir concentration in the genital tract were measured in 45 men receiving darunavir-ritonavir mono- or tritherapy. At week 48, a low frequency (3/45) of HIV-1 RNA shedding was observed in patients (1 on monotherapy and 2 on triple therapy), although they had undetectable HIV-1 RNA in plasma. The median darunavir seminal plasma concentration was close to the blood plasma free fraction, demonstrating a good penetration of darunavir into the male genital tract.

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Figures

FIG. 1.
FIG. 1.
Darunavir (DRV) concentrations in blood plasma (free- and total-protein binding) and in seminal plasma. DRV results from tritherapy and monotherapy were merged for this analysis. n, number of patients; WT, wild type.
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