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. 2010 Aug;5(8):1028-30.
doi: 10.4161/psb.5.8.12296. Epub 2010 Aug 1.

Low abundance does not mean less importance in cysteine metabolism

Cecilia Gotor  1 , Consolación Alvarez, M Angeles Bermúdez, Inmaculada Moreno, Irene García, Luis C Romero
Affiliations

Low abundance does not mean less importance in cysteine metabolism

Cecilia Gotor et al. Plant Signal Behav. 2010 Aug.

Abstract

The cysteine molecule plays an essential role in cells because it is part of proteins and because it functions as a reduced sulfur donor molecule. In addition, the cysteine molecule may also play a role in the redox signaling of different stress processes. Even though the synthesis of cysteine by the most abundant of the isoforms of O-acetylserine(thiol)lyase in the chloroplast, the mitochondria and the cytosol is relatively well-understood, the role of the other less common isoforms homologous to O-acetylserine(thiol)lyase is unknown. Several studies on two of these isoforms, one located in the cytosol and the other one in the chloroplast, have shown that while one isoform operates with a desulfhydrase activity and is essential to regulate the homeostasis of cysteine in the cytosol, the other, located in the chloroplast, synthesizes S-sulfocysteine. This metabolite appears to be essential for the redox regulation of the chloroplast under certain lighting conditions.

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Figure 1
Figure 1
Biosynthesis of cysteine and S-sulfocysteine in the chloroplast and cytosol of Arabidopsis and subcellular localization of the responsible enzymes. The cytosolic and plastidial O-acetylserine(thiol)lyase, L-cysteine desulfhydrase and S-sulfocysteine synthase are shown in red. A single representative of a grana thylakoid is shown as a grey oval compartment.
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References

    1. Wirtz M, Droux M, Hell R. O-acetylserine(thiol) lyase: an enigmatic enzyme of plant cysteine biosynthesis revisited in Arabidopsis thaliana. J Exp Bot. 2004;55:1785–1798. - PubMed
    1. Wirtz M, Droux M. Synthesis of the sulfur amino acids: cysteine and methionine. Photosyn Res. 2005;86:345–362. - PubMed
    1. Spadaro D, Yun BW, Spoel SH, Chu C, Wang YQ, Loake GJ. The redox switch: dynamic regulation of protein function by cysteine modifications. Physiol Plant. 2010;138:360–371. - PubMed
    1. Heeg C, Kruse C, Jost R, Gutensohn M, Ruppert T, Wirtz M, et al. Analysis of the Arabidopsis O-Acetylserine(thiol)lyase Gene Family Demonstrates Compartment-Specific Differences in the Regulation of Cysteine Synthesis. Plant Cell. 2008;20:168–185. - PMC - PubMed
    1. Watanabe M, Kusano M, Oikawa A, Fukushima A, Noji M, Saito K. Physiological roles of the beta-substituted alanine synthase gene family in Arabidopsis. Plant Physiol. 2008;146:310–320. - PMC - PubMed

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