Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2010 Nov;35(11):1716-24.
doi: 10.1007/s11064-010-0234-z. Epub 2010 Aug 6.

Galectin-1 enhances astrocytic BDNF production and improves functional outcome in rats following ischemia

Wen-sheng Qu  1 , Yi-hui Wang, Jian-ping Wang, Ying-xin Tang, Qiang Zhang, Dai-shi Tian, Zhi-yuan Yu, Min-jie Xie, Wei Wang
Affiliations

Galectin-1 enhances astrocytic BDNF production and improves functional outcome in rats following ischemia

Wen-sheng Qu et al. Neurochem Res. 2010 Nov.

Abstract

Galectin-1, an endogenous mammalian lectin, has been implicated in a variety of CNS disorders. However, its role in cerebral ischemia is still elusive. In the present study, we investigated the effect of recombinant galectin-1 on production of astrocytic brain-derived neurotrophic factor (BDNF) and functional recovery following ischemia. Endogenous galectin-1 was found to be markedly upregulated, paralleled with increased astrocytic BDNF production under ischemic conditions both in vitro and in vivo. Administration of galectin-1 significantly enhanced the expression and secretion of astrocytic BDNF in dose dependent manner. Moreover, rats subjected to photochemical cerebral ischemia showed reduced neuronal apoptosis in ischemic boundary zone and improved functional recovery after brain infusion of galectin-1 (1 μg/days, 7 days). These results suggest that induction of BDNF in astrocytes by galectin-1 may be a promising intervention to attenuate brain damage after stroke.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Neuroscience. 2004;125(1):171-8 - PubMed
    1. Prog Neurobiol. 2001 Jan;63(1):71-124 - PubMed
    1. Curr Drug Targets. 2005 Jun;6(4):427-36 - PubMed
    1. Eur J Immunol. 2000 May;30(5):1331-9 - PubMed
    1. J Cereb Blood Flow Metab. 1999 Aug;19(8):918-26 - PubMed

Publication types

Substances

LinkOut - more resources