Radiation pulmonary toxicity: from mechanisms to management
- PMID: 20685583
- DOI: 10.1016/j.semradonc.2010.01.010
Radiation pulmonary toxicity: from mechanisms to management
Abstract
The goal of radiation therapy is to reduce or eliminate tumor burden while sparing normal tissues from long-term injury. Thoracic radiation presents a unique challenge because of the inherent sensitivity of normal lung tissue to radiation. Damage to normal lung tissue presents a major obstacle in the treatment of individuals. To overcome this problem, a number of strategies are being used, including the modulation of dose volume, the use of image-guided radiotherapy, and the use of agents designed to reduce lung injury from radiation. Herein we discuss our current knowledge of the molecular and cellular events that occur after radiation therapy, the clinical manifestations of radiation-induced lung injury, current strategies to minimize lung injury, and recent experimental methods to reduce lung injury and their potential for translation into the clinic.
Copyright 2010 Elsevier Inc. All rights reserved.
Similar articles
-
[Importance of dosimetric factors predicting radiation toxicity in lung cancer treatment].Medicina (Kaunas). 2006;42(4):314-20. Medicina (Kaunas). 2006. PMID: 16687903 Lithuanian.
-
A little to a lot or a lot to a little? An analysis of pneumonitis risk from dose-volume histogram parameters of the lung in patients with lung cancer treated with 3-D conformal radiotherapy.Strahlenther Onkol. 2003 Aug;179(8):548-56. doi: 10.1007/s00066-003-1078-0. Strahlenther Onkol. 2003. PMID: 14509954
-
[Radiotherapy Techniques and Radiation Pneumonitis: A Lot To A Little Or A Little To A Lot?].Zhongguo Fei Ai Za Zhi. 2015 Dec;18(12):752-7. doi: 10.3779/j.issn.1009-3419.2015.12.07. Zhongguo Fei Ai Za Zhi. 2015. PMID: 26706952 Free PMC article. Review. Chinese.
-
Prediction of radiation pneumonitis by dose - volume histogram parameters in lung cancer--a systematic review.Radiother Oncol. 2004 May;71(2):127-38. doi: 10.1016/j.radonc.2004.02.015. Radiother Oncol. 2004. PMID: 15110445 Review.
-
[Relationship of dose-volume histogram parameters and computed tomography grading of radiation-induced lung injury in patients with non-small cell lung cancer treated by three-dimensional conformal radiotherapy].Zhonghua Zhong Liu Za Zhi. 2008 Sep;30(9):676-81. Zhonghua Zhong Liu Za Zhi. 2008. PMID: 19173909 Chinese.
Cited by
-
Quantitative study of lung perfusion SPECT scanning and pulmonary function testing for early radiation-induced lung injury in patients with locally advanced non-small cell lung cancer.Exp Ther Med. 2012 Apr;3(4):631-635. doi: 10.3892/etm.2012.468. Epub 2012 Jan 31. Exp Ther Med. 2012. PMID: 22969942 Free PMC article.
-
The mapping of mRNA alterations elucidates the etiology of radiation-induced pulmonary fibrosis.Front Genet. 2022 Oct 24;13:999127. doi: 10.3389/fgene.2022.999127. eCollection 2022. Front Genet. 2022. PMID: 36353104 Free PMC article.
-
Acute adaptive immune response correlates with late radiation-induced pulmonary fibrosis in mice.Radiat Oncol. 2015 Feb 20;10:45. doi: 10.1186/s13014-015-0359-y. Radiat Oncol. 2015. PMID: 25889053 Free PMC article.
-
Amelioration of Head and Neck Radiation-Induced Mucositis and Distant Marrow Suppression in Fanca-/- and Fancg-/- Mice by Intraoral Administration of GS-Nitroxide (JP4-039).Radiat Res. 2018 Jun;189(6):560-578. doi: 10.1667/RR14878.1. Epub 2018 Mar 27. Radiat Res. 2018. PMID: 29584588 Free PMC article.
-
Impact of Respiratory Developmental Stage on Sensitivity to Late Effects of Radiation in Pediatric Cancer Survivors.Adv Radiat Oncol. 2019 Dec 11;5(3):426-433. doi: 10.1016/j.adro.2019.12.002. eCollection 2020 May-Jun. Adv Radiat Oncol. 2019. PMID: 32529137 Free PMC article.
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
