Skip to main page content
U.S. flag

An official website of the United States government

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2010 Sep;20(9):568-76.
doi: 10.1016/j.tcb.2010.06.007. Epub 2010 Jul 23.

Semaphorin signaling: molecular switches at the midline

Affiliations
Review

Semaphorin signaling: molecular switches at the midline

Alwin A H A Derijck et al. Trends Cell Biol. 2010 Sep.

Abstract

To establish axonal connections growth cones must navigate multiple intermediate targets before reaching their final target. During this journey growth cones are guided by extracellular repulsive and attractive signals. Although initially identified as repulsive molecules, members of the semaphorin family include both attractants and repellents. How a navigating growth cone responds to a specific semaphorin is not absolute but instead depends on the biological context in which this cue is encountered. Here we review recent breakthroughs in our understanding of the extrinsic signals and molecular processes that control growth cone responses to class 3 semaphorins (Sema3s) at a well-characterized intermediate target, the spinal cord midline.

PubMed Disclaimer

Similar articles

Cited by

Publication types

LinkOut - more resources