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. 2010 Sep 1;16(17):4313-8.
doi: 10.1158/1078-0432.CCR-09-1942. Epub 2010 Jul 20.

New strategies in pancreatic cancer: emerging epidemiologic and therapeutic concepts

Donghui Li  1 , James L Abbruzzese
Affiliations

New strategies in pancreatic cancer: emerging epidemiologic and therapeutic concepts

Donghui Li et al. Clin Cancer Res. .

Abstract

Pancreatic cancer (PC) is a highly lethal disease with complex etiology involving both environmental and genetic factors. Although cigarette smoking is known to explain 25% of cases, data from recent studies suggest that obesity and long-term type II diabetes are two major modifiable risk factors for PC. Furthermore, obesity and diabetes seem to affect the clinical outcome of patients with PC. Understanding the mechanistic effects of obesity and diabetes on the pancreas may identify new strategies for prevention or therapy. Experimental and epidemiologic evidence suggests that the antidiabetic drug metformin has protective antitumor activity in PC. In addition to insulin resistance and inflammation as mechanisms of carcinogenesis, obesity and diabetes are linked to impairments in endothelial function and coagulation status, which increase the risks of thrombosis and angiogenesis and, in turn, the risk of PC development and progression. The associations of the ABO blood group gene and NR5A2 gene variants with PC discovered by recent genome-wide association studies may link insulin resistance, inflammation, and thrombosis to pancreatic carcinogenesis. These exciting findings open new avenues for understanding the etiology of PC and provide opportunities for developing novel strategies for prevention and treatment of this disease.

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Figures

Fig. 1
Fig. 1
Contributions of obesity and diabetes to the development and progression of pancreatic cancer.
See this image and copyright information in PMC

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References

    1. Jemal A, Siegel R, Ward E, Hao Y, Xu J, Thun MJ. Cancer statistics, 2009. CA Cancer J Clin. 2009;59:225–249. - PubMed
    1. Anderson K, Mack T, Silverman D. Cancer of the Pancreas. In: Schottenfeld D, Fraumeni J, editors. Cancer Epidemiology and Prevention. Second ed. New York: Oxford; 2006. pp. 721–762.
    1. Calle EE, Kaaks R. Overweight, obesity and cancer: epidemiological evidence and proposed mechanisms. Nat Rev Cancer. 2004;8:579–591. - PubMed
    1. Larsson SC, Orsini N, Wolk A. Body mass index and pancreatic cancer risk: a meta-analysis of prospective studies. Int J Cancer. 2007;120:1993–1998. - PubMed
    1. Li D, Morris JS, Liu J, et al. Body mass index and risk, age of onset, and survival in patients with pancreatic cancer. JAMA. 2009;301:2553–2562. - PMC - PubMed

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