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. 2010 Sep;48(9):3423-7.
doi: 10.1128/JCM.00646-10. Epub 2010 Jul 7.

New genotypes within respiratory syncytial virus group B genotype BA in Niigata, Japan

Isolde C Dapat  1 , Yugo Shobugawa, Yasuko Sano, Reiko Saito, Asami Sasaki, Yasushi Suzuki, Akihiko Kumaki, Hassan Zaraket, Clyde Dapat, Taeko Oguma, Masahiro Yamaguchi, Hiroshi Suzuki
Affiliations

New genotypes within respiratory syncytial virus group B genotype BA in Niigata, Japan

Isolde C Dapat et al. J Clin Microbiol. 2010 Sep.

Abstract

Phylogenetic analysis of respiratory syncytial virus (RSV) group B genotype BA strains from the 2002-2003 to 2009-2010 seasons collected in Niigata, Japan, revealed four distinct clusters, designated new BA genotypes BA7, BA8, BA9, and BA10. These new genotypes were not associated with large outbreaks in the community.

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Figures

FIG. 1.
FIG. 1.
Phylogenetic tree of RSV-B strains constructed by the neighbor-joining method. Partial nucleotide sequences of the second variable region of the G gene (270 to 330 bases) of strains from the 2001-2002 season to the 2009-2010 season were aligned. Reference sequences of group B genotypes from other studies were included in the analysis of the respective groups for comparison. Previously reported Niigata RSV-B BA sequences are marked with asterisks. The scale bar represents the number of nucleotide substitutions per site, and the values at the nodes are bootstrap values for 1,000 iterations. Only values of greater than 50% are shown. Genotypes are indicated at the right by brackets.
FIG. 2.
FIG. 2.
Deduced amino acid alignments of the second variable region of the G genes of representative RSV-B BA genotype strains from Niigata. Alignments are shown relative to prototype BA strain BA4128/99B (GenBank accession number AY333364), with amino acid numbers corresponding to amino acid positions 213 to 315 of the prototype sequence. Identical residues are indicated by dots, and stop codons are indicated by asterisks. The duplicated 20-amino-acid regions are underlined, and potential N-glycosylation sites are indicated by rectangles.
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