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Review
. 2010 Sep;151(9):4109-15.
doi: 10.1210/en.2010-0336. Epub 2010 Jun 23.

Minireview: Inflammation and obesity pathogenesis: the hypothalamus heats up

Joshua P Thaler  1 , Michael W Schwartz
Affiliations
Review

Minireview: Inflammation and obesity pathogenesis: the hypothalamus heats up

Joshua P Thaler et al. Endocrinology. 2010 Sep.

Abstract

Obesity induced by high-fat (HF) feeding is associated with low-grade inflammation in peripheral tissues that predisposes to insulin resistance. Recent evidence suggests the occurrence of a similar process in the hypothalamus, which favors weight gain through impairment of leptin and insulin signaling. In addition to its implications for obesity pathogenesis, this hypothesis suggests that centrally targeted antiinflammatory therapies may prove effective in prevention and treatment of this disorder. This article highlights molecular and cellular mechanisms by which hypothalamic inflammation predisposes to diet-induced obesity.

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Figures

Figure 1
Figure 1
The vicious cycle of obesity and diabetes. Energy intake in excess of energy requirements leads to a state of chronic nutrient excess that causes cellular inflammation in both peripheral tissues and the hypothalamus. The resulting activation of inflammatory pathways generates insulin and leptin resistance ultimately promoting obesity and diabetes. Therapies that prevent hypothalamic inflammation may disrupt these interlinked vicious cycles with consequent improvements in energy and glucose homeostasis.
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References

    1. Flegal KM, Carroll MD, Ogden CL, Curtin LR 2010 Prevalence and trends in obesity among U.S. adults, 1999–2008. JAMA 303:235–241 - PubMed
    1. Finkelstein EA, Trogdon JG, Cohen JW, Dietz W 2009 Annual medical spending attributable to obesity: payer- and service-specific estimates. Health Aff (Millwood) 28:w822–w831 - PubMed
    1. Svetkey LP, Stevens VJ, Brantley PJ, Appel LJ, Hollis JF, Loria CM, Vollmer WM, Gullion CM, Funk K, Smith P, Samuel-Hodge C, Myers V, Lien LF, Laferriere D, Kennedy B, Jerome GJ, Heinith F, Harsha DW, Evans P, Erlinger TP, Dalcin AT, Coughlin J, Charleston J, Champagne CM, Bauck A, Ard JD, Aicher K 2008 Comparison of strategies for sustaining weight loss: the weight loss maintenance randomized controlled trial. JAMA 299:1139–1148 - PubMed
    1. Bessesen DH 2008 Update on obesity. J Clin Endocrinol Metab 93:2027–2034 - PubMed
    1. Sjöström L, Narbro K, Sjöström CD, Karason K, Larsson B, Wedel H, Lystig T, Sullivan M, Bouchard C, Carlsson B, Bengtsson C, Dahlgren S, Gummesson A, Jacobson P, Karlsson J, Lindroos AK, Lönroth H, Näslund I, Olbers T, Stenlöf K, Torgerson J, Agren G, Carlsson LM 2007 Effects of bariatric surgery on mortality in Swedish obese subjects. N Engl J Med 357:741–752 - PubMed

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