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Review
. 2010 Jul;11(7):479-89.
doi: 10.1038/nrm2921. Epub 2010 Jun 16.

Ubiquitin signalling in DNA replication and repair

Helle D Ulrich  1 , Helen Walden
Affiliations
Review

Ubiquitin signalling in DNA replication and repair

Helle D Ulrich et al. Nat Rev Mol Cell Biol. 2010 Jul.

Abstract

Post-translational modification by ubiquitin is best known for its role in targeting its substrates for regulated degradation. However, non-proteolytic functions of the ubiquitin system, often involving either monoubiquitylation or polyubiquitylation through Lys63-linked chains, have emerged in various cell signalling pathways. These two forms of the ubiquitin signal contribute to three different pathways related to the maintenance of genome integrity that are responsible for the processing of DNA double-strand breaks, the repair of interstrand cross links and the bypass of lesions during DNA replication.

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References

    1. Curr Biol. 2009 Mar 24;19(6):524-9 - PubMed
    1. EMBO J. 2006 Oct 18;25(20):4877-87 - PubMed
    1. Mol Cell. 2006 Jan 20;21(2):187-200 - PubMed
    1. EMBO J. 2010 Feb 17;29(4):806-18 - PubMed
    1. Mol Cell. 2007 Dec 14;28(5):798-809 - PubMed

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