The ABCs of multidrug resistance in malaria
- PMID: 20541973
- DOI: 10.1016/j.pt.2010.05.002
The ABCs of multidrug resistance in malaria
Abstract
Expanding drug resistance could become a major problem in malaria treatment, as only a limited number of effective antimalarials are available. Drug resistance has been associated with single nucleotide polymorphisms and an increased copy number of multidrug resistance protein 1 (MDR1), an ATP-binding cassette (ABC) protein family member. Many ABC transport proteins are membrane transporters that actively translocate a wide range of structurally and functionally diverse amphipathic compounds. The Plasmodium falciparum ABC family consists of 16 members and current knowledge of their physiological function and contribution to antimalarial drug resistance is limited. Here, we give an overview of the Plasmodium ABC family members with reference to their possible role in multidrug resistance.
Copyright 2010 Elsevier Ltd. All rights reserved.
Similar articles
-
Complex polymorphisms in the Plasmodium falciparum multidrug resistance protein 2 gene and its contribution to antimalarial response.Antimicrob Agents Chemother. 2014 Dec;58(12):7390-7. doi: 10.1128/AAC.03337-14. Epub 2014 Sep 29. Antimicrob Agents Chemother. 2014. PMID: 25267670 Free PMC article.
-
Multidrug resistance and ABC transporters in parasitic protozoa.J Mol Microbiol Biotechnol. 2001 Apr;3(2):201-6. J Mol Microbiol Biotechnol. 2001. PMID: 11321574 Review.
-
Plasmodium chloroquine resistance and the search for a replacement antimalarial drug.Science. 2002 Oct 4;298(5591):124-6. doi: 10.1126/science.1078167. Science. 2002. PMID: 12364789
-
Vital and dispensable roles of Plasmodium multidrug resistance transporters during blood- and mosquito-stage development.Mol Microbiol. 2016 Jul;101(1):78-91. doi: 10.1111/mmi.13373. Epub 2016 May 23. Mol Microbiol. 2016. PMID: 26991313
-
The origins of antimalarial drug resistance.Trends Parasitol. 2004 Nov;20(11):512-8. doi: 10.1016/j.pt.2004.08.006. Trends Parasitol. 2004. PMID: 15471702 Review.
Cited by
-
ATM1, an essential conserved transporter in Apicomplexa, bridges mitochondrial and cytosolic [Fe-S] biogenesis.PLoS Pathog. 2024 Sep 30;20(9):e1012593. doi: 10.1371/journal.ppat.1012593. eCollection 2024 Sep. PLoS Pathog. 2024. PMID: 39348385 Free PMC article.
-
Benchmarking and Optimization of Methods for the Detection of Identity-By-Descent in High-Recombining Plasmodium falciparum Genomes.bioRxiv [Preprint]. 2024 Jul 14:2024.05.04.592538. doi: 10.1101/2024.05.04.592538. bioRxiv. 2024. PMID: 38746392 Free PMC article. Preprint.
-
Strong positive selection biases identity-by-descent-based inferences of recent demography and population structure in Plasmodium falciparum.Nat Commun. 2024 Mar 20;15(1):2499. doi: 10.1038/s41467-024-46659-0. Nat Commun. 2024. PMID: 38509066 Free PMC article.
-
Strong Positive Selection Biases Identity-By-Descent-Based Inferences of Recent Demography and Population Structure in Plasmodium falciparum.bioRxiv [Preprint]. 2023 Jul 15:2023.07.14.549114. doi: 10.1101/2023.07.14.549114. bioRxiv. 2023. Update in: Nat Commun. 2024 Mar 20;15(1):2499. doi: 10.1038/s41467-024-46659-0. PMID: 37502843 Free PMC article. Updated. Preprint.
-
The vacuolar iron transporter mediates iron detoxification in Toxoplasma gondii.Nat Commun. 2023 Jun 20;14(1):3659. doi: 10.1038/s41467-023-39436-y. Nat Commun. 2023. PMID: 37339985 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Research Materials
