Comment
doi: 10.1016/j.molcel.2010.03.003.
Stabilizing and remodeling the blocked DNA replication fork: anchoring FANCM and the Fanconi anemia damage response
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- PMID: 20347418
- DOI: 10.1016/j.molcel.2010.03.003
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Comment
Stabilizing and remodeling the blocked DNA replication fork: anchoring FANCM and the Fanconi anemia damage response
Mol Cell.
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Abstract
In this issue of Molecular Cell, Yan et al. (2010) and Singh et al. (2010) identify an evolutionarily conserved FANCM-associated histone-fold MHF heterodimer (MHF1-MHF2) that promotes the remodeling of artificial replication forks and confers cellular resistance to DNA crosslinks and camptothecin.
(c) 2010 Elsevier Inc. All rights reserved.
Comment on
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A histone-fold complex and FANCM form a conserved DNA-remodeling complex to maintain genome stability.Mol Cell. 2010 Mar 26;37(6):865-78. doi: 10.1016/j.molcel.2010.01.039. Mol Cell. 2010. PMID: 20347428 Free PMC article.
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MHF1-MHF2, a histone-fold-containing protein complex, participates in the Fanconi anemia pathway via FANCM.Mol Cell. 2010 Mar 26;37(6):879-86. doi: 10.1016/j.molcel.2010.01.036. Mol Cell. 2010. PMID: 20347429 Free PMC article.
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