Cancer metastasis as a therapeutic target

doi:10.1016/j.ejca.2010.02.039

Review

. 2010 May;46(7):1177-80.

doi: 10.1016/j.ejca.2010.02.039. Epub 2010 Mar 20.

Cancer metastasis as a therapeutic target

Jonathan Sleeman¹, Patricia S Steeg

Affiliations

PMID: 20307970
PMCID: PMC6545591
DOI: 10.1016/j.ejca.2010.02.039

Review

Cancer metastasis as a therapeutic target

Jonathan Sleeman et al. Eur J Cancer. 2010 May.

. 2010 May;46(7):1177-80.

doi: 10.1016/j.ejca.2010.02.039. Epub 2010 Mar 20.

Authors

Jonathan Sleeman¹, Patricia S Steeg

Affiliation

¹ Universitätsmedizin Mannheim, University of Heidelberg, Ludolf-Krehl-Str. 13-17, D-68167 Mannheim, Germany.

PMID: 20307970
PMCID: PMC6545591
DOI: 10.1016/j.ejca.2010.02.039

Abstract

Despite many years of basic and clinical research aimed at curbing tumour growth, metastasis remains the prime reason why cancer patients succumb to their disease. Effective translational research is urgently required, yet is not always easy to achieve. Here we review reasons why metastasis as a disease process has proven difficult to control, and suggest ways in which translational research in this area can be strengthened and advanced.

Published by Elsevier Ltd.

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Conflict of interest statement

None declared.

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References

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[1] Ferlay J, Autier P, Boniol M, et al. Estimates of the cancer incidence and mortality in Europe in 2006. Ann Oncol 2007;18(3):581–92. - PubMed

[2] Ferlay J, Autier P, Boniol M, et al. Estimates of the cancer incidence and mortality in Europe in 2006. Ann Oncol 2007;18(3):581–92. - PubMed

[3] Sporn MB. The war on cancer. Lancet 1996;347(9012):1377–81. - PubMed

[4] Sporn MB. The war on cancer. Lancet 1996;347(9012):1377–81. - PubMed

[5] Steeg PS, Theodorescu D. Metastasis: a therapeutic target for cancer. Nat Clin Pract Oncol 2008;5(4):206–19. - PMC - PubMed

[6] Steeg PS, Theodorescu D. Metastasis: a therapeutic target for cancer. Nat Clin Pract Oncol 2008;5(4):206–19. - PMC - PubMed

[7] Steeg PS. Heterogeneity of drug target expression among metastatic lesions: lessons from a breast cancer autopsy program. Clin Cancer Res 2008;14(12):3643–5. - PMC - PubMed

[8] Steeg PS. Heterogeneity of drug target expression among metastatic lesions: lessons from a breast cancer autopsy program. Clin Cancer Res 2008;14(12):3643–5. - PMC - PubMed

[9] Suit HD. Local control and patient survival. Int J Radiat Oncol Biol Phys 1992;23(3):653–60. - PubMed

[10] Suit HD. Local control and patient survival. Int J Radiat Oncol Biol Phys 1992;23(3):653–60. - PubMed

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Cancer metastasis as a therapeutic target

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Cancer metastasis as a therapeutic target

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Abstract

Conflict of interest statement

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Grants and funding

LinkOut - more resources

Full Text Sources

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