Understanding radiation-induced vascular disease

doi:10.1016/j.jacc.2009.11.053

Editorial

. 2010 Mar 23;55(12):1237-1239.

doi: 10.1016/j.jacc.2009.11.053.

Understanding radiation-induced vascular disease

Neal L Weintraub¹, W Keith Jones², David Manka³

Affiliations

¹ Department of Internal Medicine, Division of Cardiovascular Diseases, University of Cincinnati College of Medicine, Cincinnati, Ohio; Veteran's Administration Medical Center, Cincinnati, Ohio. Electronic address: neal.weintraub@uc.edu.
² Department of Pharmacology and Cell Biophysics, University of Cincinnati College of Medicine, Cincinnati, Ohio.
³ Department of Internal Medicine, Division of Cardiovascular Diseases, University of Cincinnati College of Medicine, Cincinnati, Ohio.

PMID: 20298931
PMCID: PMC3807611
DOI: 10.1016/j.jacc.2009.11.053

Editorial

Understanding radiation-induced vascular disease

Neal L Weintraub et al. J Am Coll Cardiol. 2010.

. 2010 Mar 23;55(12):1237-1239.

doi: 10.1016/j.jacc.2009.11.053.

Authors

Neal L Weintraub¹, W Keith Jones², David Manka³

Affiliations

¹ Department of Internal Medicine, Division of Cardiovascular Diseases, University of Cincinnati College of Medicine, Cincinnati, Ohio; Veteran's Administration Medical Center, Cincinnati, Ohio. Electronic address: neal.weintraub@uc.edu.
² Department of Pharmacology and Cell Biophysics, University of Cincinnati College of Medicine, Cincinnati, Ohio.
³ Department of Internal Medicine, Division of Cardiovascular Diseases, University of Cincinnati College of Medicine, Cincinnati, Ohio.

PMID: 20298931
PMCID: PMC3807611
DOI: 10.1016/j.jacc.2009.11.053

Abstract

Radiation injury of blood vessels was originally described more than a century ago and remains a contemporary clinical problem, despite dramatic advances in the field of radiation oncology (1). Clinical studies indicate that patients who have previously undergone radiation therapy for various malignancies—such as lymphoma, breast cancer, and head and neck cancer—are at increased risk for developing vascular disease (2). The consequences are significant; depending upon the study, the relative risk of suffering a clinical cardiovascular event (i.e., myocardial infarction, stroke) related to radiation therapy ranges from approximately 1.5- to 4.0-fold, and this risk is further amplified in the presence of traditional cardiovascular risk factors (3,4).

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Figures

**Figure 1. Proposed Mechanism of Involvement of NF-κB in Radiation-Induced Vascular Disease**
NF-κB = nuclear factor-kappa B.

See this image and copyright information in PMC

Comment on

Sustained inflammation due to nuclear factor-kappa B activation in irradiated human arteries.
Halle M, Gabrielsen A, Paulsson-Berne G, Gahm C, Agardh HE, Farnebo F, Tornvall P. Halle M, et al. J Am Coll Cardiol. 2010 Mar 23;55(12):1227-1236. doi: 10.1016/j.jacc.2009.10.047. J Am Coll Cardiol. 2010. PMID: 20298930

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References

1. Fajardo LF, Berthrong M. Vascular lesions following radiation. Pathol Annu. 1988;23(Pt 1):297–330. - PubMed
1. Russell NS, Hoving S, Heeneman S, et al. Novel insights into pathological changes in muscular arteries of radiotherapy patients. Radiother Oncol. 2009;92:477– 83. - PubMed
1. Fajardo LF. Is the pathology of radiation injury different in small vs large blood vessels? Cardiovasc Radiat Med. 1999;1:108–10. - PubMed
1. Hooning MJ, Botma A, Aleman BM, et al. Long-term risk of cardiovascular disease in 10-year survivors of breast cancer. J Natl Cancer Inst. 2007;99:365–75. - PubMed
1. Jurado JA, Bashir R, Burket MW. Radiation-induced peripheral artery disease. Catheter Cardiovasc Interv. 2008;72:563– 8. - PubMed

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[1] Fajardo LF, Berthrong M. Vascular lesions following radiation. Pathol Annu. 1988;23(Pt 1):297–330. - PubMed

[2] Fajardo LF, Berthrong M. Vascular lesions following radiation. Pathol Annu. 1988;23(Pt 1):297–330. - PubMed

[3] Russell NS, Hoving S, Heeneman S, et al. Novel insights into pathological changes in muscular arteries of radiotherapy patients. Radiother Oncol. 2009;92:477– 83. - PubMed

[4] Russell NS, Hoving S, Heeneman S, et al. Novel insights into pathological changes in muscular arteries of radiotherapy patients. Radiother Oncol. 2009;92:477– 83. - PubMed

[5] Fajardo LF. Is the pathology of radiation injury different in small vs large blood vessels? Cardiovasc Radiat Med. 1999;1:108–10. - PubMed

[6] Fajardo LF. Is the pathology of radiation injury different in small vs large blood vessels? Cardiovasc Radiat Med. 1999;1:108–10. - PubMed

[7] Hooning MJ, Botma A, Aleman BM, et al. Long-term risk of cardiovascular disease in 10-year survivors of breast cancer. J Natl Cancer Inst. 2007;99:365–75. - PubMed

[8] Hooning MJ, Botma A, Aleman BM, et al. Long-term risk of cardiovascular disease in 10-year survivors of breast cancer. J Natl Cancer Inst. 2007;99:365–75. - PubMed

[9] Jurado JA, Bashir R, Burket MW. Radiation-induced peripheral artery disease. Catheter Cardiovasc Interv. 2008;72:563– 8. - PubMed

[10] Jurado JA, Bashir R, Burket MW. Radiation-induced peripheral artery disease. Catheter Cardiovasc Interv. 2008;72:563– 8. - PubMed

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Understanding radiation-induced vascular disease

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Understanding radiation-induced vascular disease

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