doi: 10.1016/j.bbr.2010.02.038.
Epub 2010 Feb 26.
Effects of neurotensin in amygdaloid spatial learning mechanisms
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- PMID: 20219557
- DOI: 10.1016/j.bbr.2010.02.038
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Effects of neurotensin in amygdaloid spatial learning mechanisms
Behav Brain Res.
.
Abstract
Neurotensin (NT) acts as a neurotransmitter and/or neuromodulator and plays a role in learning and reward related processes. The central nucleus of amygdala (CeA) participates in the regulation of memory and learning mechanisms. In Morris water maze test, rats were microinjected with NT or neurotensin receptor-1 (NTS1) antagonist SR 48692 (ANT). NT significantly reduced the escape latency. Effect of NT was blocked by ANT pretreatment. Our results show that in the rat CeA NT facilitates spatial learning. We clarified that NTS1s are involved in this action.
Copyright 2010 Elsevier B.V. All rights reserved.
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