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. 2010 Jan 21:2:5.
doi: 10.1186/1758-5996-2-5.

The multiple functions of the endocannabinoid system: a focus on the regulation of food intake

Eduardo Tibiriça  1
Affiliations

The multiple functions of the endocannabinoid system: a focus on the regulation of food intake

Eduardo Tibiriça. Diabetol Metab Syndr. .

Abstract

Background: Cannabis sativa (also known as marijuana) has been cultivated by man for more than 5,000 years. However, there was a rise in its use in the 20th century for recreational, religious or spiritual, and medicinal purposes. The main psychoactive constituent of cannabis, whose structure was identified in the 1960's, is Delta9-tetrahydrocannabinol. On the other hand, the discovery of cannabinoid receptors and their endogenous agonists took place only very recently. In fact, the first cannabinoid receptor (CB1) was cloned in 1990, followed 3 years later by the characterization of a second cannabinoid receptor (CB2). Since the 19th century, the use of cannabis has been reported to stimulate appetite and increase the consumption of sweet and tasty food, sometimes resulting in significant weight gain. The recent description of the endocannabinoid system, not only in the central nervous system but also in peripheral tissues, points to its involvement in the regulation of appetite, food intake and energy metabolism. Consequently, the pharmacological modulation of the over-activity of this system could be useful in the treatment of the metabolic syndrome.

Conclusions: The endocannabinoid system has important physiological functions not only in the central nervous system but also in peripheral tissues. The activation of central CB1 receptors, particularly in hypothalamic nuclei and in the limbic system, is involved in the regulation of feeding behavior, and especially in the control of the intake of palatable food. In the periphery, cannabinoid receptors are present in adipocytes, skeletal muscle, gastrointestinal tract and liver, modulating energy metabolism.

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Figures

Figure 1
Figure 1
Both Δ9-tetrahydrocannabinol, the psychoactive component of Cannabis sativa, and anandamide, an endogenous neurotransmitter in the human brain, bind to the same cannabinoid receptor. (Photos/Diagrams from the Max Planck Institute of Psychiatry [42]).
Figure 2
Figure 2
The involvement of the endocannabinoid (EC) system over-activity in the pathophysiology of the metabolic syndrome. Adapted from [20] and [17].
See this image and copyright information in PMC

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