This site needs JavaScript to work properly. Please enable it to take advantage of the complete set of features!

Skip to main page content

Email citation

Add to Collections

Your saved search

Name of saved search:

Search terms:

Test search terms

Would you like email updates of new search results?

Yes
No

Email: (change)

Frequency:

Which day?

Which day?

Report format:

Send at most:

Send even when there aren't any new results

Optional text in email:

Your RSS Feed

Comment

. 2009 Jan 20;1(1):12-6.

doi: 10.18632/aging.100014.

Sirtuins at the breaking point: SIRT6 in DNA repair

David B Lombard¹

Affiliations

PMID: 20157593
PMCID: PMC2815760
DOI: 10.18632/aging.100014

Comment

Sirtuins at the breaking point: SIRT6 in DNA repair

David B Lombard. Aging (Albany NY). 2009.

. 2009 Jan 20;1(1):12-6.

doi: 10.18632/aging.100014.

Author

David B Lombard¹

Affiliation

¹ Department of Pathology and Institute of Gerontology, University of Michigan, Ann Arbor, MI 48109, USA. davidlom@umich.edu

PMID: 20157593
PMCID: PMC2815760
DOI: 10.18632/aging.100014

No abstract available

PubMed Disclaimer

Conflict of interest statement

The author has no conflict of interests to declare.

Comment on

SIRT6 stabilizes DNA-dependent protein kinase at chromatin for DNA double-strand break repair.
McCord RA, Michishita E, Hong T, Berber E, Boxer LD, Kusumoto R, Guan S, Shi X, Gozani O, Burlingame AL, Bohr VA, Chua KF. McCord RA, et al. Aging (Albany NY). 2009 Jan 15;1(1):109-21. doi: 10.18632/aging.100011. Aging (Albany NY). 2009. PMID: 20157594 Free PMC article.

Similar articles

SIRT6 stabilizes DNA-dependent protein kinase at chromatin for DNA double-strand break repair.
McCord RA, Michishita E, Hong T, Berber E, Boxer LD, Kusumoto R, Guan S, Shi X, Gozani O, Burlingame AL, Bohr VA, Chua KF. McCord RA, et al. Aging (Albany NY). 2009 Jan 15;1(1):109-21. doi: 10.18632/aging.100011. Aging (Albany NY). 2009. PMID: 20157594 Free PMC article.
Synergy between SIRT1 and SIRT6 helps recognize DNA breaks and potentiates the DNA damage response and repair in humans and mice.
Meng F, Qian M, Peng B, Peng L, Wang X, Zheng K, Liu Z, Tang X, Zhang S, Sun S, Cao X, Pang Q, Zhao B, Ma W, Songyang Z, Xu B, Zhu WG, Xu X, Liu B. Meng F, et al. Elife. 2020 Jun 15;9:e55828. doi: 10.7554/eLife.55828. Elife. 2020. PMID: 32538779 Free PMC article.
Sirtuins (histone deacetylases III) in the cellular response to DNA damage--facts and hypotheses.
Kruszewski M, Szumiel I. Kruszewski M, et al. DNA Repair (Amst). 2005 Nov 21;4(11):1306-13. doi: 10.1016/j.dnarep.2005.06.013. Epub 2005 Aug 3. DNA Repair (Amst). 2005. PMID: 16084131 Review.
Hungering for simplicity.
Strauss E. Strauss E. Sci Aging Knowledge Environ. 2003 May 14;2003(19):NF10. doi: 10.1126/sageke.2003.19.nf10. Sci Aging Knowledge Environ. 2003. PMID: 12844531 No abstract available.
Sirtuins and DNA damage repair: SIRT7 comes to play.
Vazquez BN, Thackray JK, Serrano L. Vazquez BN, et al. Nucleus. 2017 Mar 4;8(2):107-115. doi: 10.1080/19491034.2016.1264552. Epub 2017 Feb 17. Nucleus. 2017. PMID: 28406750 Free PMC article. Review.

See all similar articles

Cited by

SIRT6 rescues the age related decline in base excision repair in a PARP1-dependent manner.
Xu Z, Zhang L, Zhang W, Meng D, Zhang H, Jiang Y, Xu X, Van Meter M, Seluanov A, Gorbunova V, Mao Z. Xu Z, et al. Cell Cycle. 2015;14(2):269-76. doi: 10.4161/15384101.2014.980641. Cell Cycle. 2015. PMID: 25607651 Free PMC article.
Regulation of MnSOD enzymatic activity by Sirt3 connects the mitochondrial acetylome signaling networks to aging and carcinogenesis.
Tao R, Vassilopoulos A, Parisiadou L, Yan Y, Gius D. Tao R, et al. Antioxid Redox Signal. 2014 Apr 1;20(10):1646-54. doi: 10.1089/ars.2013.5482. Epub 2013 Sep 14. Antioxid Redox Signal. 2014. PMID: 23886445 Free PMC article. Review.
SIRT6, a Mammalian Deacylase with Multitasking Abilities.
Chang AR, Ferrer CM, Mostoslavsky R. Chang AR, et al. Physiol Rev. 2020 Jan 1;100(1):145-169. doi: 10.1152/physrev.00030.2018. Epub 2019 Aug 22. Physiol Rev. 2020. PMID: 31437090 Free PMC article. Review.
SIRT6-PARP1 is involved in HMGB1 polyADP-ribosylation and acetylation and promotes chemotherapy-induced autophagy in leukemia.
Kong Q, Li Y, Liang Q, Xie J, Li X, Fang J. Kong Q, et al. Cancer Biol Ther. 2020 Apr 2;21(4):320-331. doi: 10.1080/15384047.2019.1702397. Epub 2020 Jan 13. Cancer Biol Ther. 2020. PMID: 31928132 Free PMC article.
NAD⁺ centric mechanisms and molecular determinants of skeletal muscle disease and aging.
Wagner S, Manickam R, Brotto M, Tipparaju SM. Wagner S, et al. Mol Cell Biochem. 2022 Jun;477(6):1829-1848. doi: 10.1007/s11010-022-04408-1. Epub 2022 Mar 25. Mol Cell Biochem. 2022. PMID: 35334034 Free PMC article. Review.

See all "Cited by" articles

References

1. Lombard DB, Chua KF, Mostoslavsky R, Franco S, Gostissa M, Alt FW. DNA repair, genome stability, and aging. Cell. 2005;120:497–512. - PubMed
1. Yan CT, Boboila C, Souza EK, Franco S, Hickernell TR, Murphy M, Gumaste S, Geyer M, Zarrin AA, Manis JP, Rajewsky K, Alt FW. IgH class switching and translocations use a robust non-classical end-joining pathway. Nature. 2007;449:478–482. - PubMed
1. Corneo B, Wendland RL, Deriano L, Cui X, Klein IA, Wong SY, Arnal S, Holub AJ, Weller GR, Pancake BA, Shah S, Brandt VL, Meek K, Roth DB. Rag mutations reveal robust alternative end joining. Nature. 2007;449:483–486. - PubMed
1. Soulas-Sprauel P, Le Guyader G, Rivera-Munoz P, Abramowski V, Olivier-Martin C, Goujet-Zalc C, Charneau P, de Villartay JP. Role for DNA repair factor XRCC4 in immunoglobulin class switch recombination. J Exp Med. 2007;204:1717–1727. - PMC - PubMed
1. Oberdoerffer P, Michan S, McVay M, Mostoslavsky R, Vann J, Park SK, Hartlerode A, Stegmuller J, Hafner A, Loerch P, Wright SM, Mills KD, Bonni A, Yankner BA, Scully R, Prolla TA, Alt FW, Sinclair DA. SIRT1 redistribution on chromatin promotes genomic stability but alters gene expression during aging. Cell. 2008;135:907–918. - PMC - PubMed

Publication types

Actions
Actions
Actions

MeSH terms

Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions

Substances

Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions

Grants and funding

LinkOut - more resources

Full Text Sources
- Europe PubMed Central
- PubMed Central