Review
doi: 10.1016/j.sbi.2010.01.005.
Epub 2010 Feb 9.
Protein folding on the ribosome
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- PMID: 20149635
- DOI: 10.1016/j.sbi.2010.01.005
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Review
Protein folding on the ribosome
Curr Opin Struct Biol.
2010 Feb.
Abstract
In living systems, polypeptide chains are synthesised on ribosomes, molecular machines composed of over 50 protein and nucleic acid molecules. As nascent chains emerge from the ribosomal exit tunnel and into the cellular environment, the majority must fold into specific structures in order to function. In this article we discuss recent approaches designed to reveal how such folding occurs and review our current knowledge of this complex self-assembly process.
Copyright 2010. Published by Elsevier Ltd.
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