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Review
. 2010 Feb 15;70(4):1281-5.
doi: 10.1158/0008-5472.CAN-09-3276. Epub 2010 Feb 9.

Dendritic cell-derived exosomes for cancer immunotherapy: what's next?

Sophie Viaud  1 , Clotilde Théry, Stéphanie Ploix, Thomas Tursz, Valérie Lapierre, Olivier Lantz, Laurence Zitvogel, Nathalie Chaput
Affiliations
Review

Dendritic cell-derived exosomes for cancer immunotherapy: what's next?

Sophie Viaud et al. Cancer Res. .

Abstract

Exosomes are nanovesicles originating from late endosomal compartments and secreted by most living cells in ex vivo cell culture conditions. The interest in exosomes was rekindled when B-cell and dendritic cell-derived exosomes were shown to mediate MHC-dependent immune responses. Despite limited understanding of exosome biogenesis and physiological relevance, accumulating evidence points to their bioactivity culminating in clinical applications in cancer. This review focuses on the preclinical studies exploiting the immunogenicity of dendritic cell-derived exosomes (Dex) and will elaborate on the past and future vaccination trials conducted using Dex strategy in melanoma and non-small cell lung cancer patients.

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