Comparative Study
doi: 10.1126/science.2011739.
Characterization of a human TAR RNA-binding protein that activates the HIV-1 LTR
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- PMID: 2011739
- DOI: 10.1126/science.2011739
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Comparative Study
Characterization of a human TAR RNA-binding protein that activates the HIV-1 LTR
Science.
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Abstract
Human immunodeficiency virus type 1 (HIV-1) gene expression is activated by Tat, a virally encoded protein. Tat trans-activation requires viral (trans-activation--responsive; TAR) RNA sequences located in the R region of the long terminal repeat (LTR). Existing evidence suggests that Tat probably cooperates with cellular factors that bind to TAR RNA in the overall trans-activation process. A HeLa complementary DNA was isolated and characterized that encodes a TAR RNA-binding protein (TRBP). TRBP activated the HIV-1 LTR and was synergistic with Tat function.
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