Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2009 Dec:1182:69-79.
doi: 10.1111/j.1749-6632.2009.05069.x.

Clinical Use of Interferon-gamma

Affiliations
Review

Clinical Use of Interferon-gamma

Catriona H T Miller et al. Ann N Y Acad Sci. 2009 Dec.

Abstract

Interferon gamma (IFN-gamma), a pleotropic cytokine, has been shown to be important to the function of virtually all immune cells and both innate and adaptive immune responses. In 1986, early clinical trials of this cytokine began to evaluate its therapeutic potential. The initial studies focused on the tolerability and pharmacology of IFN-gamma and systematically determined its antitumor and anti-infection activities. In the 20-plus years since those first trials, IFN-gamma has been used in a wide variety of clinical indications, which are reviewed in this article.

PubMed Disclaimer

Conflict of interest statement

Conflicts of Interest

The authors declare no conflicts of interest.

Similar articles

Cited by

References

    1. Young HA, Romero-Weaver AL, Savan R, et al. 2007. Interferon-gamma. Interferon-γ in Class II Cytokines Zdanov A, Ed.: 51–106. Research Signpost, Kerala, India.
    1. Jaffe HS & Sherwin SA. 1986. The early clinical trials of recombinant human interferon-gamma. Interferons as Cell Growth Inhibitors and Antitumor Factors Freedman R, Merigan T & Sreevalson T, Eds.: 37–46. Alan R. Liss; New York.
    1. Condos R, Hull FP, Schluger NW, et al. 2004. Regional deposition of aerosolized interferon-gamma in pulmonary tuberculosis. Chest 125: 2146–2155. - PubMed
    1. Suarez-Mendez R, Garcia-Garcia I, Fernandez-Olivera N, et al. 2004. Adjuvant interferon gamma in patients with drug-resistant pulmonary tuberculosis: A pilot study. BMC Infect. Dis 4: 44. - PMC - PubMed
    1. Soza A, Heller T, Ghany M, et al. 2005. Pilot study of interferon gamma for chronic hepatitis C. J. Hepatol 43: 67–71. - PubMed

Publication types

Substances