The immunomodulatory roles of macrophages at the maternal-fetal interface
- PMID: 20065301
- DOI: 10.1177/1933719109349962
The immunomodulatory roles of macrophages at the maternal-fetal interface
Abstract
Macrophages are versatile cells that play a central role in innate and adaptive immunity and participate in a wide variety of biological processes. In the uterine decidua, macrophages represent a major leukocyte subset throughout pregnancy. Here, decidual macrophages exert an immunosuppressive phenotype characterized by abundant production of interleukin (IL)-10 and indoleamine 2,3-dioxygenase activity. Their polarized cytokine secretion pattern has recently been classified as an M2 phenotype. These features of decidual macrophages favor maternal immune tolerance to semiallogenic fetus. In addition, macrophages cooperate with trophoblast cells during the early stages of human pregnancy to support uterine vasculature remodeling by removing apoptotic cells and through the production of proteases that degrade the extracellular matrix. In the peripartum period, macrophages also participate in the regulation of cervical ripening and the initiation of parturition through the production of proinflammatory cytokines and prostaglandin E(2) (PGE(2)). Aberrant activity of uterine macrophages is linked to the pathogenesis of preeclampsia and preterm delivery. Here, we review the immunomodulatory roles of decidual macrophages during pregnancy.
Similar articles
-
The contribution of macrophages to normal and pathological pregnancies.Am J Reprod Immunol. 2010 Jun;63(6):460-71. doi: 10.1111/j.1600-0897.2010.00813.x. Epub 2010 Feb 16. Am J Reprod Immunol. 2010. PMID: 20163399 Review.
-
Pre-eclampsia is associated with dendritic cell recruitment into the uterine decidua.J Pathol. 2008 Feb;214(3):328-36. doi: 10.1002/path.2257. J Pathol. 2008. PMID: 18069648
-
The role of macrophages in utero-placental interactions during normal and pathological pregnancy.Immunol Invest. 2008;37(5):535-64. doi: 10.1080/08820130802191375. Immunol Invest. 2008. PMID: 18716937 Review.
-
Macrophages and apoptotic cell clearance during pregnancy.Am J Reprod Immunol. 2004 Apr;51(4):275-82. doi: 10.1111/j.1600-0897.2004.00156.x. Am J Reprod Immunol. 2004. PMID: 15212680 Review.
-
Trophoblast debris modulates the expression of immune proteins in macrophages: a key to maternal tolerance of the fetal allograft?J Reprod Immunol. 2012 Jun;94(2):131-41. doi: 10.1016/j.jri.2012.03.488. Epub 2012 Apr 27. J Reprod Immunol. 2012. PMID: 22542910
Cited by
-
β3-Adrenoceptors as Putative Regulator of Immune Tolerance in Cancer and Pregnancy.Front Immunol. 2020 Sep 2;11:2098. doi: 10.3389/fimmu.2020.02098. eCollection 2020. Front Immunol. 2020. PMID: 32983164 Free PMC article.
-
Gene model-related m6A expression levels predict the risk of preeclampsia.BMC Med Genomics. 2022 May 5;15(1):103. doi: 10.1186/s12920-022-01254-4. BMC Med Genomics. 2022. PMID: 35513840 Free PMC article.
-
Cyclooxygenase (COX)-2 Inhibitors Reduce Toxoplasma gondii Infection and Upregulate the Pro-inflammatory Immune Response in Calomys callosus Rodents and Human Monocyte Cell Line.Front Microbiol. 2019 Feb 12;10:225. doi: 10.3389/fmicb.2019.00225. eCollection 2019. Front Microbiol. 2019. PMID: 30809216 Free PMC article.
-
PGE(2) suppression of innate immunity during mucosal bacterial infection.Front Cell Infect Microbiol. 2013 Aug 21;3:45. doi: 10.3389/fcimb.2013.00045. eCollection 2013. Front Cell Infect Microbiol. 2013. PMID: 23971009 Free PMC article. Review.
-
HLA Class Ib Molecules and Immune Cells in Pregnancy and Preeclampsia.Front Immunol. 2014 Dec 23;5:652. doi: 10.3389/fimmu.2014.00652. eCollection 2014. Front Immunol. 2014. PMID: 25566263 Free PMC article. Review.
