doi: 10.1271/bbb.90568.
Epub 2010 Jan 7.
Inhibitory effect of curcumin on IMP dehydrogenase, the target for anticancer and antiviral chemotherapy agents
Affiliations
- PMID: 20057137
- DOI: 10.1271/bbb.90568
Item in Clipboard
Inhibitory effect of curcumin on IMP dehydrogenase, the target for anticancer and antiviral chemotherapy agents
Biosci Biotechnol Biochem.
2010.
Free article
Abstract
Inosine monophosphate dehydrogenase (IMPDH), a rate-limiting enzyme in the de novo synthesis of guanine nucleotides, is a therapeutic target for anticancer and antiviral agents. Among the 15 different polyphenols examined, curcumin was found to have an inhibitory effect on the IMPDH activity in both a competitive and uncompetitive manner and to suppress the cellular GTP level in HT-29 colon carcinoma cells.
Similar articles
-
Inosine monophosphate dehydrogenase as a target for antiviral, anticancer, antimicrobial and immunosuppressive therapeutics.Future Med Chem. 2010 Jan;2(1):81-92. doi: 10.4155/fmc.09.147. Future Med Chem. 2010. PMID: 21426047 Review.
-
[The determination and clinical application of inosine 5’-monophosphate dehydrogenase activity].Yao Xue Xue Bao. 2016 Nov;51(11):1666-73. Yao Xue Xue Bao. 2016. PMID: 29908108 Review. Chinese.
-
Novel inhibitors of inosine monophosphate dehydrogenase in patent literature of the last decade.Recent Pat Anticancer Drug Discov. 2013 May;8(2):103-25. Recent Pat Anticancer Drug Discov. 2013. PMID: 23016672 Review.
-
Inosine monophosphate dehydrogenase as a probe in antiviral drug discovery.Antivir Chem Chemother. 2007;18(5):245-58. doi: 10.1177/095632020701800501. Antivir Chem Chemother. 2007. PMID: 18046958 Review.
-
Effects of the IMP-dehydrogenase inhibitor, Tiazofurin, in bcr-abl positive acute myelogenous leukemia. Part II. In vitro studies.Leuk Res. 2004 Nov;28(11):1137-43. doi: 10.1016/j.leukres.2004.03.004. Leuk Res. 2004. PMID: 15380336
Cited by
-
Proliferation inhibition, cell cycle arrest and apoptosis induced in HL-60 cells by a natural diterpene ester from Daphne mucronata.Daru. 2011;19(2):145-53. Daru. 2011. PMID: 22615651 Free PMC article.
-
Curcumin and Photobiomodulation in Chronic Viral Hepatitis and Hepatocellular Carcinoma.Int J Mol Sci. 2020 Sep 28;21(19):7150. doi: 10.3390/ijms21197150. Int J Mol Sci. 2020. PMID: 32998270 Free PMC article. Review.
-
The targets of curcumin.Curr Drug Targets. 2011 Mar 1;12(3):332-47. doi: 10.2174/138945011794815356. Curr Drug Targets. 2011. PMID: 20955148 Free PMC article. Review.
-
Effect of curcuminoids and curcumin derivate products on thioredoxin-glutathione reductase from Taenia crassiceps cysticerci. Evidence suggesting a curcumin oxidation product as a suitable inhibitor.PLoS One. 2019 Jul 22;14(7):e0220098. doi: 10.1371/journal.pone.0220098. eCollection 2019. PLoS One. 2019. PMID: 31329647 Free PMC article.
-
A review on antibacterial, antiviral, and antifungal activity of curcumin.Biomed Res Int. 2014;2014:186864. doi: 10.1155/2014/186864. Epub 2014 Apr 29. Biomed Res Int. 2014. PMID: 24877064 Free PMC article. Review.
