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Review
. 2010 Jan;10(1):73-8.
doi: 10.1038/nri2687. Epub 2009 Dec 11.

Proteasomes in immune cells: more than peptide producers?

Marcus Groettrup  1 , Christopher J Kirk, Michael Basler
Affiliations
Review

Proteasomes in immune cells: more than peptide producers?

Marcus Groettrup et al. Nat Rev Immunol. 2010 Jan.

Abstract

When cells are stimulated with pro-inflammatory cytokines, most of their constitutively expressed proteasomes are replaced with immunoproteasomes, which increase the production of peptides for presentation on MHC class I molecules. In addition, cortical thymic epithelial cells selectively express a type of proteasome known as the thymoproteasome that is required for the positive selection of thymocytes. Here, we discuss how these specialized types of proteasome shape the T cell receptor repertoire of cytotoxic T lymphocytes and propose that immunoproteasomes have functions, in addition to antigen processing, that influence cytokine production and T cell differentiation, survival and function. We also discuss how inhibitors of immunoproteasomes can suppress undesired T cell responses in autoimmune diseases.

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References

    1. Science. 1995 Apr 28;268(5210):579-82 - PubMed
    1. Nature. 1991 Oct 17;353(6345):662-4 - PubMed
    1. J Exp Med. 1994 Mar 1;179(3):901-9 - PubMed
    1. J Biol Chem. 1992 Nov 5;267(31):22369-77 - PubMed
    1. J Exp Med. 2001 Jun 4;193(11):1319-26 - PubMed

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