HPMA copolymer-cyclic RGD conjugates for tumor targeting
- PMID: 19951733
- DOI: 10.1016/j.addr.2009.11.027
HPMA copolymer-cyclic RGD conjugates for tumor targeting
Abstract
This review describes the design and development of N-(2-hydroxypropyl)-methacrylamide (HPMA) copolymer-cyclic RGD conjugates for targeting tumor angiogenesis. Relative to non-targetable systems, HPMA copolymer-RGD4C and -RGDfK conjugates have shown increased tumor accumulation in a variety of solid tumors including prostate, lung, and breast tumor xenografts. Compared to free peptides, copolymers had increased tumor accumulation and decreased uptake in non-target organs such as the liver and spleen. Clinically relevant imaging agents such as (99m)Tc, (111)In, and Gd enabled in vivo imaging of the constructs by scintigraphy and magnetic resonance techniques. Targeted delivery of (90)Y, a radiotherapeutic agent by HPMA copolymer-RGD4C conjugates resulted in tumor size reduction in mice bearing prostate tumor xenografts. Delivery of the geldanamycin derivative 17-(6-aminohexylamino)-17-demethoxygeldanamycin by HPMA copolymer-RGDfK conjugates resulted in increased tumor concentration of the free drug in a prostate xenograft model. These constructs show promise for targeted delivery of therapeutics and imaging agents to solid tumors.
Copyright 2009 Elsevier B.V. All rights reserved.
Similar articles
-
Targeting tumor angiogenesis: comparison of peptide and polymer-peptide conjugates.J Nucl Med. 2005 Sep;46(9):1552-60. J Nucl Med. 2005. PMID: 16157540
-
Targeting tumor angiogenic vasculature using polymer-RGD conjugates.J Control Release. 2005 Jan 20;102(1):191-201. doi: 10.1016/j.jconrel.2004.09.023. J Control Release. 2005. PMID: 15653145
-
Molecular imaging of HPMA copolymers: visualizing drug delivery in cell, mouse and man.Adv Drug Deliv Rev. 2010 Feb 17;62(2):246-57. doi: 10.1016/j.addr.2009.12.007. Epub 2010 Jan 7. Adv Drug Deliv Rev. 2010. PMID: 20060431 Review.
-
[Biodistribution of N-(2-hydroxypropyl) methacrylamide copolymer-bound mitoxantrone in mice bearing Ehrlich solid tumor].Sheng Wu Yi Xue Gong Cheng Xue Za Zhi. 2004 Dec;21(6):930-4. Sheng Wu Yi Xue Gong Cheng Xue Za Zhi. 2004. PMID: 15646335 Chinese.
-
Improving the efficacy of combined modality anticancer therapy using HPMA copolymer-based nanomedicine formulations.Adv Drug Deliv Rev. 2010 Feb 17;62(2):203-30. doi: 10.1016/j.addr.2009.11.028. Epub 2009 Dec 4. Adv Drug Deliv Rev. 2010. PMID: 19951732 Review.
Cited by
-
Glucocorticoid-loaded core-cross-linked polymeric micelles with tailorable release kinetics for targeted therapy of rheumatoid arthritis.Angew Chem Int Ed Engl. 2012 Jul 16;51(29):7254-8. doi: 10.1002/anie.201202713. Epub 2012 Jun 12. Angew Chem Int Ed Engl. 2012. PMID: 22692876 Free PMC article.
-
Gold nanorod-mediated hyperthermia enhances the efficacy of HPMA copolymer-90Y conjugates in treatment of prostate tumors.Nucl Med Biol. 2014 Mar;41(3):282-9. doi: 10.1016/j.nucmedbio.2013.12.002. Epub 2013 Dec 10. Nucl Med Biol. 2014. PMID: 24461626 Free PMC article.
-
Polymeric Systems for Cancer Immunotherapy: A Review.Front Immunol. 2022 Feb 22;13:826876. doi: 10.3389/fimmu.2022.826876. eCollection 2022. Front Immunol. 2022. PMID: 35273607 Free PMC article. Review.
-
Polymeric conjugates for drug delivery.Chem Mater. 2012 Mar 13;24(5):840-853. doi: 10.1021/cm2031569. Epub 2012 Jan 4. Chem Mater. 2012. PMID: 22707853 Free PMC article.
-
Engineering antiphagocytic biomimetic drug carriers.Ther Deliv. 2013 Jul;4(7):825-39. doi: 10.4155/tde.13.54. Ther Deliv. 2013. PMID: 23883126 Free PMC article. Review.
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources
Other Literature Sources
