The effect of carbon nanotubes on drug delivery in an electro-sensitive transdermal drug delivery system
- PMID: 19931904
- DOI: 10.1016/j.biomaterials.2009.11.004
The effect of carbon nanotubes on drug delivery in an electro-sensitive transdermal drug delivery system
Abstract
An electro-sensitive transdermal drug delivery system was prepared by the electrospinning method to control drug release. A semi-interpenetrating polymer network was prepared as the matrix with polyethylene oxide and pentaerythritol triacrylate polymers. Multi-walled carbon nanotubes were used as an additive to increase the electrical sensitivity. The release experiment was carried out under different electric voltage conditions. Carbon nanotubes were observed in the middle of the electrospun fibers by SEM and TEM. The amount of released drug was effectively increased with higher applied electric voltages. These results were attributed to the excellent electrical conductivity of the carbon additive. The suggested mechanism of drug release involves polyethylene oxide of the semi-interpenetrating polymer network being dissolved under the effects of carbon nanotubes, thereby releasing the drug. The effects of the electro-sensitive transdermal drug delivery system were enhanced by the carbon nanotubes.
(c) 2009 Elsevier Ltd. All rights reserved.
Similar articles
-
Polymer-derived ceramic composite fibers with aligned pristine multiwalled carbon nanotubes.ACS Appl Mater Interfaces. 2010 Apr;2(4):1150-6. doi: 10.1021/am1000085. ACS Appl Mater Interfaces. 2010. PMID: 20423134
-
Carbon nanotubes for transdermal drug delivery.J Microencapsul. 2010;27(8):669-81. doi: 10.3109/02652048.2010.506581. Epub 2010 Aug 6. J Microencapsul. 2010. PMID: 20690793
-
Double-layer weekly sustained release transdermal patch containing gestodene and ethinylestradiol.Int J Pharm. 2009 Jul 30;377(1-2):128-34. doi: 10.1016/j.ijpharm.2009.05.017. Epub 2009 May 20. Int J Pharm. 2009. PMID: 19463930
-
Transdermal drug delivery: clinical considerations for the obstetrician-gynecologist.Obstet Gynecol. 2005 May;105(5 Pt 1):953-61. doi: 10.1097/01.AOG.0000161958.70059.db. Obstet Gynecol. 2005. PMID: 15863530 Review.
-
A feasible way to use carbon nanotubes to deliver drug molecules: transdermal application.Expert Opin Drug Deliv. 2012 Aug;9(8):991-9. doi: 10.1517/17425247.2012.696607. Epub 2012 Jun 5. Expert Opin Drug Deliv. 2012. PMID: 22663542 Review.
Cited by
-
Pharmaceutical and biomedical applications of surface engineered carbon nanotubes.Drug Discov Today. 2015 Jun;20(6):750-9. doi: 10.1016/j.drudis.2015.01.006. Epub 2015 Jan 17. Drug Discov Today. 2015. PMID: 25601411 Free PMC article. Review.
-
Electroactive Smart Polymers for Biomedical Applications.Materials (Basel). 2019 Jan 16;12(2):277. doi: 10.3390/ma12020277. Materials (Basel). 2019. PMID: 30654487 Free PMC article. Review.
-
Injectable and Conductive Granular Hydrogels for 3D Printing and Electroactive Tissue Support.Adv Sci (Weinh). 2019 Aug 21;6(20):1901229. doi: 10.1002/advs.201901229. eCollection 2019 Oct 16. Adv Sci (Weinh). 2019. PMID: 31637164 Free PMC article.
-
Carbon nanotubes hybrid hydrogels in drug delivery: a perspective review.Biomed Res Int. 2014;2014:825017. doi: 10.1155/2014/825017. Epub 2014 Jan 21. Biomed Res Int. 2014. PMID: 24587993 Free PMC article. Review.
-
Design strategies for physical-stimuli-responsive programmable nanotherapeutics.Drug Discov Today. 2018 May;23(5):992-1006. doi: 10.1016/j.drudis.2018.04.003. Epub 2018 Apr 10. Drug Discov Today. 2018. PMID: 29653291 Free PMC article. Review.
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
