Thermoresponsive self-assembled elastin-based nanoparticles for delivery of BMPs
- PMID: 19913578
- DOI: 10.1016/j.jconrel.2009.11.003
Thermoresponsive self-assembled elastin-based nanoparticles for delivery of BMPs
Abstract
Elastin-like polymers are a new type of protein-based polymers that display interesting properties in the biomaterial field. Bone morphogenetic proteins (BMPs) are cytokines with a strong ability to promote new bone formation. In this work, we explored the use of elastin-like nanoparticles (average size 237.5+/-3.0 nm), created by thermoresponsive self-assembly, for the combined release of bone morphogenetic protein-2 (BMP-2) and bone morphogenetic protein-14 (BMP-14). These BMPs could be encapsulated at high efficiency into the elastin-like particles and delivered in a sustained way for 14 days. The activity of the growth factors was retained, as shown by the induction of ALP activity and osteogenic mineralization in C2C12 cells. Increased bioactivity was observed with a combined release of BMP-2 and BMP-14. This approach shows a significant potential for future tissue engineering applications in bone.
(c) 2009 Elsevier B.V. All rights reserved.
Similar articles
-
Self-assembled particles of an elastin-like polymer as vehicles for controlled drug release.J Control Release. 2005 Jan 20;102(1):113-22. doi: 10.1016/j.jconrel.2004.10.001. J Control Release. 2005. PMID: 15653138
-
Bone morphogenic protein-2 (BMP-2) loaded nanoparticles mixed with human mesenchymal stem cell in fibrin hydrogel for bone tissue engineering.J Biosci Bioeng. 2009 Dec;108(6):530-7. doi: 10.1016/j.jbiosc.2009.05.021. J Biosci Bioeng. 2009. PMID: 19914589
-
Silk fibroin microparticles as carriers for delivery of human recombinant bone morphogenetic protein-2: in vitro and in vivo bioactivity.Tissue Eng Part C Methods. 2010 Oct;16(5):937-45. doi: 10.1089/ten.TEC.2009.0486. Tissue Eng Part C Methods. 2010. PMID: 19958078
-
Cell responses to bone morphogenetic proteins and peptides derived from them: biomedical applications and limitations.Cytokine Growth Factor Rev. 2009 Jun;20(3):213-22. doi: 10.1016/j.cytogfr.2009.05.006. Epub 2009 Jun 2. Cytokine Growth Factor Rev. 2009. PMID: 19493693 Review.
-
Bone morphogenetic proteins in tissue engineering: the road from laboratory to clinic, part II (BMP delivery).J Tissue Eng Regen Med. 2008 Mar-Apr;2(2-3):81-96. doi: 10.1002/term.74. J Tissue Eng Regen Med. 2008. PMID: 18383454 Review.
Cited by
-
Strategies for controlled delivery of growth factors and cells for bone regeneration.Adv Drug Deliv Rev. 2012 Sep;64(12):1292-309. doi: 10.1016/j.addr.2012.01.016. Epub 2012 Feb 4. Adv Drug Deliv Rev. 2012. PMID: 22342771 Free PMC article. Review.
-
Engineering biomolecular systems: Controlling the self-assembly of gelatin to form ultra-small bioactive nanomaterials.Bioact Mater. 2022 Mar 14;18:321-336. doi: 10.1016/j.bioactmat.2022.02.035. eCollection 2022 Dec. Bioact Mater. 2022. PMID: 35415301 Free PMC article.
-
Thermo-targeted drug delivery of geldanamycin to hyperthermic tumor margins with diblock elastin-based biopolymers.J Control Release. 2011 Oct 30;155(2):175-83. doi: 10.1016/j.jconrel.2011.07.040. Epub 2011 Aug 7. J Control Release. 2011. PMID: 21846483 Free PMC article.
-
Biocompatible and biodegradable fibrinogen microspheres for tumor-targeted doxorubicin delivery.Int J Nanomedicine. 2015 Sep 1;10 Spec Iss(Spec Iss):101-11. doi: 10.2147/IJN.S88381. eCollection 2015. Int J Nanomedicine. 2015. PMID: 26366073 Free PMC article.
-
Evaluation of machine learning algorithms to predict the hydrodynamic radii and transition temperatures of chemo-biologically synthesized copolymers.Comput Biol Med. 2021 Jan;128:104134. doi: 10.1016/j.compbiomed.2020.104134. Epub 2020 Nov 21. Comput Biol Med. 2021. PMID: 33249343 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
