Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1991 Jun;2(3):228-34.
doi: 10.1016/1044-7431(91)90049-t.

Neuronal localization of tyrosine hydroxylase gene products in human neocortex

D A Lewis  1 , D S Melchitzky, A Gioio, Z Solomon, B B Kaplan
Affiliations

Neuronal localization of tyrosine hydroxylase gene products in human neocortex

D A Lewis et al. Mol Cell Neurosci. 1991 Jun.

Abstract

Tyrosine hydroxylase (TH), the rate-limiting enzyme in catecholamine biosynthesis, has been reported to be present in interneurons in human cerebral cortex. In this study, immunocytochemical analysis using monoclonal anti-TH antibodies was employed to demonstrate the specific expression of tyrosine hydroxylase protein by a distinct subpopulation of nonpyramidal neurons in human neocortex. These neurons were present in greatest density in layer VI of limbic and higher order association regions. The presence of TH gene products in human neocortex was confirmed by the demonstration, using both in situ hybridization histochemistry and polymerase chain reaction methodology, that the mRNA for human TH is expressed in human neocortex. These findings raise important questions regarding the role played by these TH-containing neurons in human neocortical function.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

LinkOut - more resources