The vanilloid transient receptor potential channel TRPV4: from structure to disease
- PMID: 19835908
- DOI: 10.1016/j.pbiomolbio.2009.10.002
The vanilloid transient receptor potential channel TRPV4: from structure to disease
Abstract
The Transient Receptor Potential Vanilloid 4 channel, TRPV4, is a Ca(2+) and Mg(2+) permeable non-selective cation channel involved in many different cellular functions. It is activated by a variety of physical and chemical stimuli, including heat, mechano-stimuli, endogenous substances such as arachidonic acid and its cytochrome P450-derived metabolites (epoxyeicosatrienoic acids), endocannabinoids (anandamide and 2-arachidonoylglycerol), as well as synthetic alpha-phorbol derivatives. Recently, TRPV4 has been characterized as an important player modulating osteoclast differentiation in bone remodelling and as a urothelial mechanosensor that controls normal voiding. Several TRPV4 gain-of-function mutations are shown to cause autosomal-dominant bone dysplasias such as brachyolmia and Koszlowski disease. In this review we comprehensively describe the structural, biophysical and (patho)physiological properties of the TRPV4 channel and we summarize the current knowledge about the role of TRPV4 in the pathogenesis of several diseases.
2009 Elsevier Ltd. All rights reserved.
Similar articles
-
Characterization of transient receptor potential vanilloid channel 4 (TRPV4) in human corneal endothelial cells.Exp Eye Res. 2011 Nov;93(5):710-9. doi: 10.1016/j.exer.2011.09.021. Epub 2011 Oct 6. Exp Eye Res. 2011. PMID: 21996372
-
Expression and functional characterization of transient receptor potential vanilloid-related channel 4 (TRPV4) in rat cortical astrocytes.Neuroscience. 2007 Sep 21;148(4):876-92. doi: 10.1016/j.neuroscience.2007.06.039. Epub 2007 Jul 17. Neuroscience. 2007. PMID: 17719182
-
TRPV4.Handb Exp Pharmacol. 2007;(179):189-205. doi: 10.1007/978-3-540-34891-7_11. Handb Exp Pharmacol. 2007. PMID: 17217058 Review.
-
On the origin of bladder sensing: Tr(i)ps in urology.Neurourol Urodyn. 2008;27(4):264-73. doi: 10.1002/nau.20511. Neurourol Urodyn. 2008. PMID: 17849480 Review.
-
Modulation of the Ca2 permeable cation channel TRPV4 by cytochrome P450 epoxygenases in vascular endothelium.Circ Res. 2005 Oct 28;97(9):908-15. doi: 10.1161/01.RES.0000187474.47805.30. Epub 2005 Sep 22. Circ Res. 2005. PMID: 16179585
Cited by
-
Type 2 diabetes associated changes in the plasma non-esterified fatty acids, oxylipins and endocannabinoids.PLoS One. 2012;7(11):e48852. doi: 10.1371/journal.pone.0048852. Epub 2012 Nov 8. PLoS One. 2012. PMID: 23144998 Free PMC article.
-
Astrocyte regulation of cerebral vascular tone.Am J Physiol Heart Circ Physiol. 2013 Sep 1;305(5):H609-19. doi: 10.1152/ajpheart.00359.2013. Epub 2013 Jun 21. Am J Physiol Heart Circ Physiol. 2013. PMID: 23792684 Free PMC article. Review.
-
The expression profile of a multi-stress inducible transient receptor potential vanilloid 4 (TRPV4) in Pacific oyster Crassostrea gigas.Fish Shellfish Immunol Rep. 2022 Aug 15;3:100064. doi: 10.1016/j.fsirep.2022.100064. eCollection 2022 Dec. Fish Shellfish Immunol Rep. 2022. PMID: 36419610 Free PMC article.
-
Modulation of TRPV4 protects against degeneration induced by sustained loading and promotes matrix synthesis in the intervertebral disc.FASEB J. 2023 Feb;37(2):e22714. doi: 10.1096/fj.202201388R. FASEB J. 2023. PMID: 36583692 Free PMC article.
-
Wild-type and brachyolmia-causing mutant TRPV4 channels respond directly to stretch force.J Biol Chem. 2010 Aug 27;285(35):27176-27181. doi: 10.1074/jbc.M110.143370. Epub 2010 Jul 6. J Biol Chem. 2010. PMID: 20605796 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
Molecular Biology Databases
Miscellaneous
