Lipid abnormalities predict progression of renal disease in patients with type 1 diabetes

doi:10.1007/s00125-009-1541-2

. 2009 Dec;52(12):2522-30.

doi: 10.1007/s00125-009-1541-2. Epub 2009 Oct 10.

Lipid abnormalities predict progression of renal disease in patients with type 1 diabetes

N Tolonen¹, C Forsblom, L Thorn, J Wadén, M Rosengård-Bärlund, M Saraheimo, M Feodoroff, V-P Mäkinen, D Gordin, M-R Taskinen, P-H Groop; FinnDiane Study Group

Collaborators, Affiliations

Collaborators

FinnDiane Study Group:
S Koivula, T Uggeldahl, T Forslund, A Halonen, A Koistinen, P Koskiaho, M Laukkanen, J Saltevo, M Tiihonen, A-C Blomqvist, M Forsen, H Granlund, B Nyroos, P Kinnunen, A Orvola, T Salonen, A Vähänen, R Paldanius, M Riihelä, L Ryysy, P Nyländen, A Sademies, S Anderson, B Asplund, U Byskata, T Virkkala, A Nikkola, E Ritola, L Penttinen, H-L Siekkinen, A Kaprio, J Kärkkaäinen, B Rantaeskola, S Klemetti, T Nyandoto, E Rontu, S Satuli-Autere, R Toivonen, H Virtanen, M Laine, T Pellonpää, R Puranen, A Airas, J Laakso, K Rautavaara, M Erola, E Jatkola, R Lönnblad, A Malm, J Mäkelä, E Rautamo, P Hentunen, J Lagerstam, H Rosvall, T Kalliomäki, J Koskelainen, R Nikkanen, N Savolainen, H Sulonen, E Valtonen, E Toivanen, A Parta, I Pirttiniem, S Aranko, S Ervasti, R Kauppinen-Mäkelin, A Kuusisto, T Leppälä, K Nikkilä, L Pekkonen, S Jokelainen, P Kemppainen, A-M Mankinen, M Sankari, A Aimolahti, E Huovinen, V Ilkka, M Lehtimäki, E Koskinen, T Siitonen, E Huttunen, R Ikäheimo, P Karhapää, P Kekäläinen, M Laakso, T Lakka, E Lampainen, L Mykkänen, L Niskanen, U Tuovinen, I Vauhkonen, E Voutilainen, E Kilkki, L Riihelä, T Meriläinen, P Poukka, R Savolainen, N Uhlenius, A Mäkelä, M Tanner, L Hyvärinen, S Severinkangas, T Tulokas, P Linkola, I Pulli, T Granlund, M Saari, T Salonen, I-M Jousmaa, J Rinne, H Lanki, S Moilanen, M Tilly-Kiesi, A Gynther, R Manninen, P Nironen, M Salminen, T Vänttinen, U-M Henttula, A Rissanen, P Kekäläinen, M Voutilainen, E Jokelainen, P-L Jylkkä, E Kaarlela, J Vuolaspuro, L Hiltunen, R Häkkinen, S Keinänen-Kiukaanniemi, H Haapamäki, A Helanterä, H Miettinen, P Sopanen, L Welling, K Mäkinen, P Sopanen, V Javtsenko, M Tamminen, M-L Holmbäck, B Isomaa, P Ahonen, P Merensalo, K Sävelä, M Kallio, B Rask, A Holma, M Honkala, A Tuomivaara, R Vainionpää, K Laine, K Saarinen, T Salminen, E Immonen, L Juurinen, A Alanko, J Lapinleimu, P Rautio, M Virtanen, M Asola, M Juhola, P Kunelius, M-L Lahdenmäki, P Pääkkönen, M Rautavirta, T Pulli, P Sallinen, E Tolvanen, H Valtonen, A Vartia, E Korpi, T Latvala, E Leijala, T Hotti, R Härkönen, U Nyholm, J Toivanen, I Ala-Houhala, T Kuningas, P Lampinen, M Määttä, H Oksala, T Oksanen, K Salonen, H Tauriainen, S Tulokas, T Kivelä, L Petlin, L Savolainen, I Hämäläinen, H Virtamo, M Vähätalo, K Breitholz, R Eskola, K Metsärinne, U Pietilä, P Saarinen, R Tuominen, S Ayräpää, I Isomäki, R Kroneld, M Tapiolinna-Mäkelä, S Bergkulla, U Hautamäki, V-A Myllyniemi, I Rusk

Affiliation

¹ Folkhälsan Institute of Genetics, Folkhälsan Research Center, University of Helsinki, Biomedicum Helsinki (C318b), Haartmaninkatu 8, PO Box 63, 00014, Helsinki, Finland.

PMID: 19816673
DOI: 10.1007/s00125-009-1541-2

Lipid abnormalities predict progression of renal disease in patients with type 1 diabetes

N Tolonen et al. Diabetologia. 2009 Dec.

. 2009 Dec;52(12):2522-30.

doi: 10.1007/s00125-009-1541-2. Epub 2009 Oct 10.

Authors

N Tolonen¹, C Forsblom, L Thorn, J Wadén, M Rosengård-Bärlund, M Saraheimo, M Feodoroff, V-P Mäkinen, D Gordin, M-R Taskinen, P-H Groop; FinnDiane Study Group

Collaborators

FinnDiane Study Group:
S Koivula, T Uggeldahl, T Forslund, A Halonen, A Koistinen, P Koskiaho, M Laukkanen, J Saltevo, M Tiihonen, A-C Blomqvist, M Forsen, H Granlund, B Nyroos, P Kinnunen, A Orvola, T Salonen, A Vähänen, R Paldanius, M Riihelä, L Ryysy, P Nyländen, A Sademies, S Anderson, B Asplund, U Byskata, T Virkkala, A Nikkola, E Ritola, L Penttinen, H-L Siekkinen, A Kaprio, J Kärkkaäinen, B Rantaeskola, S Klemetti, T Nyandoto, E Rontu, S Satuli-Autere, R Toivonen, H Virtanen, M Laine, T Pellonpää, R Puranen, A Airas, J Laakso, K Rautavaara, M Erola, E Jatkola, R Lönnblad, A Malm, J Mäkelä, E Rautamo, P Hentunen, J Lagerstam, H Rosvall, T Kalliomäki, J Koskelainen, R Nikkanen, N Savolainen, H Sulonen, E Valtonen, E Toivanen, A Parta, I Pirttiniem, S Aranko, S Ervasti, R Kauppinen-Mäkelin, A Kuusisto, T Leppälä, K Nikkilä, L Pekkonen, S Jokelainen, P Kemppainen, A-M Mankinen, M Sankari, A Aimolahti, E Huovinen, V Ilkka, M Lehtimäki, E Koskinen, T Siitonen, E Huttunen, R Ikäheimo, P Karhapää, P Kekäläinen, M Laakso, T Lakka, E Lampainen, L Mykkänen, L Niskanen, U Tuovinen, I Vauhkonen, E Voutilainen, E Kilkki, L Riihelä, T Meriläinen, P Poukka, R Savolainen, N Uhlenius, A Mäkelä, M Tanner, L Hyvärinen, S Severinkangas, T Tulokas, P Linkola, I Pulli, T Granlund, M Saari, T Salonen, I-M Jousmaa, J Rinne, H Lanki, S Moilanen, M Tilly-Kiesi, A Gynther, R Manninen, P Nironen, M Salminen, T Vänttinen, U-M Henttula, A Rissanen, P Kekäläinen, M Voutilainen, E Jokelainen, P-L Jylkkä, E Kaarlela, J Vuolaspuro, L Hiltunen, R Häkkinen, S Keinänen-Kiukaanniemi, H Haapamäki, A Helanterä, H Miettinen, P Sopanen, L Welling, K Mäkinen, P Sopanen, V Javtsenko, M Tamminen, M-L Holmbäck, B Isomaa, P Ahonen, P Merensalo, K Sävelä, M Kallio, B Rask, A Holma, M Honkala, A Tuomivaara, R Vainionpää, K Laine, K Saarinen, T Salminen, E Immonen, L Juurinen, A Alanko, J Lapinleimu, P Rautio, M Virtanen, M Asola, M Juhola, P Kunelius, M-L Lahdenmäki, P Pääkkönen, M Rautavirta, T Pulli, P Sallinen, E Tolvanen, H Valtonen, A Vartia, E Korpi, T Latvala, E Leijala, T Hotti, R Härkönen, U Nyholm, J Toivanen, I Ala-Houhala, T Kuningas, P Lampinen, M Määttä, H Oksala, T Oksanen, K Salonen, H Tauriainen, S Tulokas, T Kivelä, L Petlin, L Savolainen, I Hämäläinen, H Virtamo, M Vähätalo, K Breitholz, R Eskola, K Metsärinne, U Pietilä, P Saarinen, R Tuominen, S Ayräpää, I Isomäki, R Kroneld, M Tapiolinna-Mäkelä, S Bergkulla, U Hautamäki, V-A Myllyniemi, I Rusk

Affiliation

¹ Folkhälsan Institute of Genetics, Folkhälsan Research Center, University of Helsinki, Biomedicum Helsinki (C318b), Haartmaninkatu 8, PO Box 63, 00014, Helsinki, Finland.

PMID: 19816673
DOI: 10.1007/s00125-009-1541-2

Abstract

Aims/hypothesis: We studied the impact of baseline lipid variables on the progression of renal disease in a large nationwide prospective cohort of patients with type 1 diabetes.

Methods: A total of 2,304 adult patients with type 1 diabetes and available lipid profiles participating in the Finnish Diabetic Nephropathy Study (FinnDiane) were evaluated. Data on progression of renal disease were verified from medical files and patients were followed for 5.4 +/- 2.0 (mean +/- SD) years.

Results: High triacylglycerol, apolipoprotein (Apo) B, ApoA-II and HDL(3)-cholesterol concentrations predicted incident microalbuminuria. Progression to macroalbuminuria was predicted by high triacylglycerol and ApoB. When AER was entered into the model, triacylglycerol was no longer an independent predictor, but when patients with normal AER and microalbuminuria at baseline were pooled, triacylglycerol, HbA(1c), male sex and AER were all independent predictors of renal disease. High total cholesterol, LDL-cholesterol, non-HDL-cholesterol and triacylglycerol as well as low HDL-cholesterol, HDL(2)-cholesterol, ApoA-I and ApoA-II concentrations were predictive of progression to end-stage renal disease. However, when estimated GFR was entered into the model, only total cholesterol remained an independent predictor of progression.

Conclusions/interpretation: Lipid abnormalities, particularly high triacylglycerol concentrations, increase the risk of progression of renal disease.

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References

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[1] BMJ. 1989 Jul 22;299(6693):230-3 - PubMed

[2] BMJ. 1989 Jul 22;299(6693):230-3 - PubMed

[3] Kidney Int. 2001 Jul;60(1):219-27 - PubMed

[4] Kidney Int. 2001 Jul;60(1):219-27 - PubMed

[5] Arterioscler Thromb Vasc Biol. 1997 Apr;17(4):715-22 - PubMed

[6] Arterioscler Thromb Vasc Biol. 1997 Apr;17(4):715-22 - PubMed

[7] J Am Soc Nephrol. 2006 Jul;17(7):2006-16 - PubMed

[8] J Am Soc Nephrol. 2006 Jul;17(7):2006-16 - PubMed

[9] Diabetologia. 1998 Jul;41(7):784-90 - PubMed

[10] Diabetologia. 1998 Jul;41(7):784-90 - PubMed

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Lipid abnormalities predict progression of renal disease in patients with type 1 diabetes

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Lipid abnormalities predict progression of renal disease in patients with type 1 diabetes

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