doi: 10.1126/science.1179052.
Epub 2009 Oct 8.
Detection of an infectious retrovirus, XMRV, in blood cells of patients with chronic fatigue syndrome
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- PMID: 19815723
- DOI: 10.1126/science.1179052
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Detection of an infectious retrovirus, XMRV, in blood cells of patients with chronic fatigue syndrome
Science.
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Erratum in
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Partial retraction. Detection of an infectious retrovirus, XMRV, in blood cells of patients with chronic fatigue syndrome.Science. 2011 Oct 14;334(6053):176. doi: 10.1126/science.1212182. Science. 2011. PMID: 21998366 No abstract available.
Retraction in
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Retraction.Science. 2011 Dec 23;334(6063):1636. doi: 10.1126/science.334.6063.1636-a. Science. 2011. PMID: 22194552
Expression of concern in
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Editorial expression of concern.Science. 2011 Jul 1;333(6038):35. doi: 10.1126/science.1208542. Science. 2011. PMID: 21719658 No abstract available.
Abstract
Chronic fatigue syndrome (CFS) is a debilitating disease of unknown etiology that is estimated to affect 17 million people worldwide. Studying peripheral blood mononuclear cells (PBMCs) from CFS patients, we identified DNA from a human gammaretrovirus, xenotropic murine leukemia virus-related virus (XMRV), in 68 of 101 patients (67%) as compared to 8 of 218 (3.7%) healthy controls. Cell culture experiments revealed that patient-derived XMRV is infectious and that both cell-associated and cell-free transmission of the virus are possible. Secondary viral infections were established in uninfected primary lymphocytes and indicator cell lines after their exposure to activated PBMCs, B cells, T cells, or plasma derived from CFS patients. These findings raise the possibility that XMRV may be a contributing factor in the pathogenesis of CFS.
Comment in
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Virology. A new virus for old diseases?Science. 2009 Oct 23;326(5952):530-1. doi: 10.1126/science.1181349. Epub 2009 Oct 8. Science. 2009. PMID: 19815721 Free PMC article.
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Comment on "Detection of an infectious retrovirus, XMRV, in blood cells of patients with chronic fatigue syndrome".Science. 2010 May 14;328(5980):825; author reply 825. doi: 10.1126/science.1183906. Science. 2010. PMID: 20466904
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Comment on "Detection of an infectious retrovirus, XMRV, in blood cells of patients with chronic fatigue syndrome".Science. 2010 May 14;328(5980):825; author reply 825. doi: 10.1126/science.1183706. Science. 2010. PMID: 20466905
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Comment on "Detection of an infectious retrovirus, XMRV, in blood cells of patients with chronic fatigue syndrome".Science. 2010 May 14;328(5980):825; author reply 825. doi: 10.1126/science.1183545. Science. 2010. PMID: 20466906
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Virology. A new virus for old diseases?Science. 2009 Oct 23;326(5952):530-1. doi: 10.1126/science.1181349. Epub 2009 Oct 8. Science. 2009. PMID: 19815721 Free PMC article.
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Comment on "Detection of an infectious retrovirus, XMRV, in blood cells of patients with chronic fatigue syndrome".Science. 2010 May 14;328(5980):825; author reply 825. doi: 10.1126/science.1183906. Science. 2010. PMID: 20466904
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