Cerebral cortical vasodilatation in response to stimulation of cholinergic fibres originating in the nucleus basalis of Meynert
- PMID: 1976668
- DOI: 10.1016/0165-1838(90)90118-3
Cerebral cortical vasodilatation in response to stimulation of cholinergic fibres originating in the nucleus basalis of Meynert
Abstract
The recent works in our laboratory, concerning neural regulation of the cerebral cortical blood flow by intracranial cholinergic nerve fibres originating in the magnocellular nucleus of the basal forebrain (nucleus basalis of Meynert), are introduced. Unilateral focal stimulation of the nucleus basalis of Meynert, either electrical or chemical, increased blood flow in the ipsilateral cerebral cortex in rats anesthetized with urethane or halothane. These vasodilator responses were almost completely abolished by intravenous administrations of muscarinic and nicotinic cholinergic blocking agents (atropine 0.5 mg/kg and mecamylamine 2 mg/kg). Electrical or chemical stimulation of the nucleus basalis of Meynert increased acetylcholine release in the ipsilateral cerebral cortex. These data suggest that intracranial cholinergic fibres originating in the nucleus basalis of Meynert and projecting to the cerebral cortex contribute to the vasodilatation of the cortical blood vessels.
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