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. 2010 Jan;108(1):191-5.
doi: 10.1007/s00421-009-1192-5. Epub 2009 Sep 16.

Relationship of an advanced glycation end product, plasma carboxymethyl-lysine, with slow walking speed in older adults: the InCHIANTI study

Richard D Semba  1 , Stefania Bandinelli, Kai Sun, Jack M Guralnik, Luigi Ferrucci
Affiliations

Relationship of an advanced glycation end product, plasma carboxymethyl-lysine, with slow walking speed in older adults: the InCHIANTI study

Richard D Semba et al. Eur J Appl Physiol. 2010 Jan.

Abstract

Advanced glycation end products (AGEs) are bioactive molecules found in foods and generated endogenously in the body. AGEs induce cross-linking of collagen and increase the stiffness of skeletal muscle and cartilage. We characterized the relationship between a plasma AGE, carboxymethyl-lysine (CML), and slow walking speed (lowest quintile of walking speed) in older adults. Walking speed over a 4 m course was assessed in 944 adults, aged >or=65 years, in the InCHIANTI study, a population-based study of aging and mobility disability conducted in two towns in Tuscany, Italy. Participants in the highest quartile of plasma CML were at higher risk of slow walking speed (Odds Ratio [O.R.] 1.56, 95% Confidence Interval [C.I.] 1.02-2.38, P = 0.04) compared to those in the lower three quartiles of plasma CML in a logistic regression models adjusting for age, education, cognitive function, smoking, and chronic diseases. After exclusion of participants with diabetes, participants in the highest quartile of plasma CML were at higher risk of slow walking speed (O.R. 1.87, 95% C.I. 1.15-3.04, P = 0.01) adjusting for the same covariates. In older community-dwelling adults, elevated plasma CML is independently associated with slow walking speed.

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References

    1. Bandinelli S, Pozzi M, Lauretani F, Phillips C, Shumway-Cook A, Guralnik JM, Ferrucci L. Adding challenge to performance-based tests of walking: The Walking InCHIANTI Toolkit (WIT) Am J Phys Med Rehabil. 2006;85:986–991. - PMC - PubMed
    1. Basta G, Schmidt AM, de Caterina R. Advanced glycation end products and vascular inflammation: implications for accelerated atherosclerosis in diabetes. Cardiovasc Res. 2004;63:582–592. - PubMed
    1. Boehm BO, Schilling S, Rosinger S, Lang GE, Lang GK, Kietsch-Engel R, Stahl P. Elevated serum levels of Nε-carboxymethyl-lysine, an advanced glycation end product, are associated with proliferative diabetic retinopathy and macular oedema. Diabetologia. 2004;47:1376–1379. - PubMed
    1. Bohlender JM, Franke S, Stein G, Wolf G. Advanced glycation end products and the kidney. Am J Renal Physiol. 2005;289:F645–F659. - PubMed
    1. Dalal M, Ferrucci L, Sun K, Beck J, Fried LP, Semba RD. Elevated serum advanced glycation end products and poor grip strength in older community-dwelling women. J Gerontol A Biol Sci Med Sci. 2009;64:132–137. - PMC - PubMed

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