doi: 10.1016/0092-8674(90)90262-d.
A developmental switch in thymic lymphocyte maturation potential occurs at the level of hematopoietic stem cells
Affiliations
- PMID: 1975515
- DOI: 10.1016/0092-8674(90)90262-d
Item in Clipboard
A developmental switch in thymic lymphocyte maturation potential occurs at the level of hematopoietic stem cells
Cell.
.
Free article
Abstract
Hematopoietic stem cells (HSCs) isolated from mouse fetal liver, like adult HSCs, are Thy-1lo Lin- Sca-1+. Donor-derived V gamma 3+ T cells were detected in fetal thymic lobes repopulated in vitro with fetal liver HSCs, but not in those with adult bone marrow HSCs. Single clonogenic fetal HSCs gave rise to thymic progeny that include V gamma 3+, other gamma delta+, and alpha beta+ T cells. No V gamma 3+ T cells were detected in adult thymus injected intrathymically with either fetal or adult HSCs. These results support the hypothesis that only fetal HSCs have the capacity to differentiate into V gamma 3+ T cells in the fetal thymic microenvironment and that the developmental potential of HSCs may change during ontogeny.
Similar articles
-
Development of gamma delta T-cell subsets from fetal hematopoietic stem cells.Ann N Y Acad Sci. 1992 May 4;651:21-32. doi: 10.1111/j.1749-6632.1992.tb24590.x. Ann N Y Acad Sci. 1992. PMID: 1599125
-
Human CD34+ fetal liver stem cells differentiate to T cells in a mouse thymic microenvironment.Blood. 1994 Sep 1;84(5):1587-93. Blood. 1994. PMID: 7520780
-
Similar rates of production of T and B lymphocytes in the bone marrow.J Exp Med. 1995 Jun 1;181(6):2201-11. doi: 10.1084/jem.181.6.2201. J Exp Med. 1995. PMID: 7760006 Free PMC article.
-
Lymphocyte development from stem cells.Annu Rev Immunol. 1992;10:759-83. doi: 10.1146/annurev.iy.10.040192.003551. Annu Rev Immunol. 1992. PMID: 1375474 Review.
-
The role of fetal epithelial tissues in the maturation/differentiation of bone marrow-derived precursors into dendritic epidermal T cells (DETC) of the mouse.Curr Top Microbiol Immunol. 1991;173:269-77. doi: 10.1007/978-3-642-76492-9_37. Curr Top Microbiol Immunol. 1991. PMID: 1833153 Review.
Cited by
-
Transcriptional network dynamics in early T cell development.J Exp Med. 2024 Oct 7;221(10):e20230893. doi: 10.1084/jem.20230893. Epub 2024 Aug 21. J Exp Med. 2024. PMID: 39167073 Free PMC article. Review.
-
Thymic development of unconventional T cells: how NKT cells, MAIT cells and γδ T cells emerge.Nat Rev Immunol. 2020 Dec;20(12):756-770. doi: 10.1038/s41577-020-0345-y. Epub 2020 Jun 24. Nat Rev Immunol. 2020. PMID: 32581346 Review.
-
Prospects for chimeric antigen receptor (CAR) γδ T cells: A potential game changer for adoptive T cell cancer immunotherapy.Cancer Lett. 2016 Oct 1;380(2):413-423. doi: 10.1016/j.canlet.2016.07.001. Epub 2016 Jul 5. Cancer Lett. 2016. PMID: 27392648 Free PMC article. Review.
-
A wave of bipotent T/ILC-restricted progenitors shapes the embryonic thymus microenvironment in a time-dependent manner.Blood. 2021 Feb 25;137(8):1024-1036. doi: 10.1182/blood.2020006779. Blood. 2021. PMID: 33025012 Free PMC article.
-
S179D prolactin diminishes the effects of UV light on epidermal gamma delta T cells.Mol Cell Endocrinol. 2008 Jan 2;280(1-2):6-12. doi: 10.1016/j.mce.2007.09.004. Epub 2007 Sep 11. Mol Cell Endocrinol. 2008. PMID: 17945411 Free PMC article.
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
Molecular Biology Databases
Research Materials
