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. 1977 Jul;74(7):3078-80.
doi: 10.1073/pnas.74.7.3078.

Electrical stimulation of preganglionic nerve increases tyrosine hydroxylase activity in sympathetic ganglia

R E Zigmond, Y Ben-Ari

Electrical stimulation of preganglionic nerve increases tyrosine hydroxylase activity in sympathetic ganglia

R E Zigmond et al. Proc Natl Acad Sci U S A. 1977 Jul.

Abstract

The effect of synaptic stimulation on tyrosine hydroxylase [tyrosine 3-monooxygenase: L-tyrosine, tetrahydropteridine:oxygen oxidoreductase (3-hydroxylating), EC 1.14.16.2] activity in the rat superior cervical ganglion was studied. The preganglionic cervical sympathetic trunk was stimulated unilaterally at 10 Hz for 30 min. Forty-eight hours later tyrosine hydroxylase activity was 33% higher on the stimulated than on the control side. The enzyme activity restimulated than on the control side. The enzyme activity remained elevated in the stimulated ganglia for 2 days. No change was observed in total ganglion protein. Comparable increases in tyrosine hydroxylase activity were observed in anesthetized and conscious animals.

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References

    1. J Physiol. 1960 Jan;150:114-33 - PubMed
    1. J Biol Chem. 1951 Nov;193(1):265-75 - PubMed
    1. J Physiol. 1975 Jun;248(1):48P-49P - PubMed
    1. J Neurochem. 1973 Jun;20(6):1683-9 - PubMed
    1. Proc Natl Acad Sci U S A. 1973 Oct;70(10):2767-71 - PubMed

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