Cytomegalovirus-induced gammadelta T cells associate with reduced cancer risk after kidney transplantation
- PMID: 19713314
- PMCID: PMC2799280
- DOI: 10.1681/ASN.2008101072
Cytomegalovirus-induced gammadelta T cells associate with reduced cancer risk after kidney transplantation
Abstract
An increase in the number of blood gammadelta T cells follows cytomegalovirus (CMV) infection in kidney transplant recipients. These cells react against CMV-infected cells and tumor epithelial cells in vitro. We hypothesized that these CMV-induced gammadelta T cells play a protective role against cancer in kidney transplant recipients. We performed a longitudinal case-control study involving 18 recipients who developed cancer between 2 and 6 yr after transplantation and 45 recipients who did not. The median percentage of gammadelta T cells among total lymphocytes in patients with malignancies was significantly lower compared with that in control patients at 6, 12, and 18 mo before the diagnosis of cancer. Patients with a gammadelta T cell percentage of more than 4% were protected from cancer. An increase of the Vdelta2(neg) gammadelta T cell subset significantly associated with lower incidence of cancer only in recipients who experienced pre- or postgraft CMV infection. Finally, a retrospective follow-up of 131 recipients for 8 yr revealed that CMV-naive recipients had an approximately 5-fold higher risk of cancer compared with CMV-exposed patients. In summary, these results suggest a protective role of CMV exposure against cancer in kidney transplant recipients.
Figures



Comment in
-
Protection from cancer in kidney transplant patients by gammadelta T cells: role of CMV infection?J Am Soc Nephrol. 2010 Jan;21(1):11-3. doi: 10.1681/ASN.2009111166. Epub 2009 Dec 10. J Am Soc Nephrol. 2010. PMID: 20007750 No abstract available.
Similar articles
-
Protection from cancer in kidney transplant patients by gammadelta T cells: role of CMV infection?J Am Soc Nephrol. 2010 Jan;21(1):11-3. doi: 10.1681/ASN.2009111166. Epub 2009 Dec 10. J Am Soc Nephrol. 2010. PMID: 20007750 No abstract available.
-
Expansion of effector memory Vδ2neg γδ T cells associates with cytomegalovirus reactivation in allogeneic stem cell transplant recipients.Front Immunol. 2024 Jun 10;15:1397483. doi: 10.3389/fimmu.2024.1397483. eCollection 2024. Front Immunol. 2024. PMID: 38915409 Free PMC article.
-
Cytomegalovirus infection in transplant recipients resolves when circulating gammadelta T lymphocytes expand, suggesting a protective antiviral role.J Infect Dis. 2001 Sep 1;184(5):533-41. doi: 10.1086/322843. Epub 2001 Jul 31. J Infect Dis. 2001. PMID: 11494158
-
Direct and Indirect Effects of Cytomegalovirus-Induced γδ T Cells after Kidney Transplantation.Front Immunol. 2015 Jan 21;6:3. doi: 10.3389/fimmu.2015.00003. eCollection 2015. Front Immunol. 2015. PMID: 25653652 Free PMC article. Review.
-
Revisiting the Role of γδ T Cells in Anti-CMV Immune Response after Transplantation.Viruses. 2021 May 29;13(6):1031. doi: 10.3390/v13061031. Viruses. 2021. PMID: 34072610 Free PMC article. Review.
Cited by
-
The complex existence of γδ T cells following transplantation: the good, the bad and the simply confusing.Clin Transl Immunology. 2019 Sep 17;8(9):e1078. doi: 10.1002/cti2.1078. eCollection 2019. Clin Transl Immunology. 2019. PMID: 31548887 Free PMC article. Review.
-
The emerging role of γδ T cells in cancer immunotherapy.Immunooncol Technol. 2019 Jun 26;1:3-10. doi: 10.1016/j.iotech.2019.06.002. eCollection 2019 Jul. Immunooncol Technol. 2019. PMID: 35755322 Free PMC article. Review.
-
Peripheral blood T-cell signatures from high-resolution immune phenotyping of γδ and αβ T-cells in younger and older subjects in the Berlin Aging Study II.Immun Ageing. 2015 Dec 4;12:25. doi: 10.1186/s12979-015-0052-x. eCollection 2015. Immun Ageing. 2015. PMID: 26640505 Free PMC article.
-
Phased differentiation of γδ T and T CD8 tumor-infiltrating lymphocytes revealed by single-cell transcriptomics of human cancers.Oncoimmunology. 2021 Sep 18;10(1):1939518. doi: 10.1080/2162402X.2021.1939518. eCollection 2021. Oncoimmunology. 2021. PMID: 34721945 Free PMC article.
-
Cytomegalovirus-responsive γδ T cells: novel effector cells in antibody-mediated kidney allograft microcirculation lesions.J Am Soc Nephrol. 2014 Nov;25(11):2471-82. doi: 10.1681/ASN.2013101052. Epub 2014 Apr 17. J Am Soc Nephrol. 2014. PMID: 24744438 Free PMC article.
References
-
- Webster AC, Craig JC, Simpson JM, Jones MP, Chapman JR: Identifying high risk groups and quantifying absolute risk of cancer after kidney transplantation: A cohort study of 15,183 recipients. Am J Transplant 7: 2140–2151, 2007 - PubMed
-
- Vajdic CM, McDonald SP, McCredie MR, van Leeuwen MT, Stewart JH, Law M, Chapman JR, Webster AC, Kaldor JM, Grulich AE: Cancer incidence before and after kidney transplantation. JAMA 296: 2823–2831, 2006 - PubMed
-
- Kasiske BL, Snyder JJ, Gilbertson DT, Wang C: Cancer after kidney transplantation in the United States. Am J Transplant 4: 905–913, 2004 - PubMed
-
- Ramsay HM, Fryer AA, Hawley CM, Smith AG, Harden PN: Non-melanoma skin cancer risk in the Queensland renal transplant population. Br J Dermatol 147: 950–956, 2002 - PubMed
-
- Shankaran V, Ikeda H, Bruce AT, White JM, Swanson PE, Old LJ, Schreiber RD: IFNgamma and lymphocytes prevent primary tumour development and shape tumour immunogenicity. Nature 410: 1107–1111, 2001 - PubMed
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical