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. 2009 Sep 23;131(37):13320-7.
doi: 10.1021/ja902894s.

Instability of cationic gold nanoparticle bioconjugates: the role of citrate ions

Isaac Ojea-Jiménez  1 , Victor Puntes
Affiliations

Instability of cationic gold nanoparticle bioconjugates: the role of citrate ions

Isaac Ojea-Jiménez et al. J Am Chem Soc. .

Erratum in

  • J Am Chem Soc. 2010 Apr 14;132(14):5322

Abstract

Gold nanoparticles of 6, 8, and 16 nm, synthesized with HAuCl(4) and sodium citrate, were derived with biomolecules based on the peptide CIPGNVG and possessing different terminal charges. We have studied the stability of these conjugates as a function of ionic strength, pH, and the presence of other species in solution. It was observed that multiple electrostatic interactions between the conjugates mediated by cross-linking species led to an effective strong bond and consequently to irreversible aggregation and precipitation. In the presence of citrate or diamine ions, nanoparticles precipitated when two-headed ions had charges opposite (and therefore attractive) to the conjugate, thus acting as bridging molecules. This effect depends on the pH, the concentration of particles, and their size, and it is relevant to designing bioconjugates for biomedical applications.

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