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. 2009 Sep 24;23(15):2050-4.
doi: 10.1097/QAD.0b013e3283303e04.

Persistent HIV RNA shedding in semen despite effective antiretroviral therapy

Prameet M Sheth  1 , Colin Kovacs, Kimdar S Kemal, R Brad Jones, Janet M Raboud, Richard Pilon, Charles la Porte, Mario Ostrowski, Mona Loutfy, Harold Burger, Barbara Weiser, Rupert Kaul; Toronto Mucosal Immunology Group
Collaborators, Affiliations

Persistent HIV RNA shedding in semen despite effective antiretroviral therapy

Prameet M Sheth et al. AIDS. .

Abstract

Effective antiretroviral therapy (ART) may reduce HIV sexual transmission by lowering genital HIV levels. A prospective study of men starting ART (n = 25) demonstrated rapid, substantial reductions in semen HIV RNA. However, despite an undetectable blood viral load, isolated semen HIV shedding was detected at more than one visit in 12 of 25 (48%) participants, with semen HIV RNA levels exceeding 5000 copies/ml in four of 25 (16%). Isolates were drug-sensitive, and this phenomenon was not associated with semen drug levels or regimen.

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