Skeletal muscle lipotoxicity in insulin resistance and type 2 diabetes

doi:10.1113/jphysiol.2009.177758

. 2009 Aug 15;587(Pt 16):3977-8.

doi: 10.1113/jphysiol.2009.177758.

Skeletal muscle lipotoxicity in insulin resistance and type 2 diabetes

Charlotte Brøns¹, Allan Vaag

Affiliations

PMID: 19684225
PMCID: PMC2756432
DOI: 10.1113/jphysiol.2009.177758

Skeletal muscle lipotoxicity in insulin resistance and type 2 diabetes

Charlotte Brøns et al. J Physiol. 2009.

. 2009 Aug 15;587(Pt 16):3977-8.

doi: 10.1113/jphysiol.2009.177758.

Authors

Charlotte Brøns¹, Allan Vaag

Affiliation

¹ Steno Diabetes Center, Niels Steensensvej 2, 2820 Gentofte, Denmark. avaa@steno.dk

PMID: 19684225
PMCID: PMC2756432
DOI: 10.1113/jphysiol.2009.177758

No abstract available

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References

1. Brøns C, Jensen CB, Storgaard H, Hiscock NJ, White A, Appel JS, Jacobsen S, Nilsson E, Larsen CM, Astrup A, Quistorff B, Vaag A. Impact of short-term high-fat feeding on glucose and insulin metabolism in young healthy men. J Physiol. 2009;587:2387–2397. - PMC - PubMed
1. Koves TR, Ussher JR, Noland RC, Slentz D, Mosedale M, Ilkayeva O, Bain J, Stevens R, Dyck JR, Newgard CB, Lopaschuk GD, Muoio DM. Mitochondrial overload and incomplete fatty acid oxidation contribute to skeletal muscle insulin resistance. Cell Metab. 2008;7:45–56. - PubMed
1. Morley JE. Diabetes, sarcopenia, and frailty. Clin Geriatr Med. 2008;24:455–469. - PubMed
1. Petersen KF, Dufour S, Shulman GI. Decreased insulin-stimulated ATP synthesis and phosphate transport in muscle of insulin-resistant offspring of type 2 diabetic parents. PLoS Med. 2005;2:e233. - PMC - PubMed
1. Randle PJ, Garland PB, Hales CN, Newsholme EA. The glucose fatty-acid cycle. Its role in insulin sensitivity and the metabolic disturbances of diabetes mellitus. Lancet. 1963;1:785–789. - PubMed

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[1] Brøns C, Jensen CB, Storgaard H, Hiscock NJ, White A, Appel JS, Jacobsen S, Nilsson E, Larsen CM, Astrup A, Quistorff B, Vaag A. Impact of short-term high-fat feeding on glucose and insulin metabolism in young healthy men. J Physiol. 2009;587:2387–2397. - PMC - PubMed

[2] Brøns C, Jensen CB, Storgaard H, Hiscock NJ, White A, Appel JS, Jacobsen S, Nilsson E, Larsen CM, Astrup A, Quistorff B, Vaag A. Impact of short-term high-fat feeding on glucose and insulin metabolism in young healthy men. J Physiol. 2009;587:2387–2397. - PMC - PubMed

[3] Koves TR, Ussher JR, Noland RC, Slentz D, Mosedale M, Ilkayeva O, Bain J, Stevens R, Dyck JR, Newgard CB, Lopaschuk GD, Muoio DM. Mitochondrial overload and incomplete fatty acid oxidation contribute to skeletal muscle insulin resistance. Cell Metab. 2008;7:45–56. - PubMed

[4] Koves TR, Ussher JR, Noland RC, Slentz D, Mosedale M, Ilkayeva O, Bain J, Stevens R, Dyck JR, Newgard CB, Lopaschuk GD, Muoio DM. Mitochondrial overload and incomplete fatty acid oxidation contribute to skeletal muscle insulin resistance. Cell Metab. 2008;7:45–56. - PubMed

[5] Morley JE. Diabetes, sarcopenia, and frailty. Clin Geriatr Med. 2008;24:455–469. - PubMed

[6] Morley JE. Diabetes, sarcopenia, and frailty. Clin Geriatr Med. 2008;24:455–469. - PubMed

[7] Petersen KF, Dufour S, Shulman GI. Decreased insulin-stimulated ATP synthesis and phosphate transport in muscle of insulin-resistant offspring of type 2 diabetic parents. PLoS Med. 2005;2:e233. - PMC - PubMed

[8] Petersen KF, Dufour S, Shulman GI. Decreased insulin-stimulated ATP synthesis and phosphate transport in muscle of insulin-resistant offspring of type 2 diabetic parents. PLoS Med. 2005;2:e233. - PMC - PubMed

[9] Randle PJ, Garland PB, Hales CN, Newsholme EA. The glucose fatty-acid cycle. Its role in insulin sensitivity and the metabolic disturbances of diabetes mellitus. Lancet. 1963;1:785–789. - PubMed

[10] Randle PJ, Garland PB, Hales CN, Newsholme EA. The glucose fatty-acid cycle. Its role in insulin sensitivity and the metabolic disturbances of diabetes mellitus. Lancet. 1963;1:785–789. - PubMed

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Skeletal muscle lipotoxicity in insulin resistance and type 2 diabetes

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Skeletal muscle lipotoxicity in insulin resistance and type 2 diabetes

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