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Review
. 2010 Feb;9(4):224-8.
doi: 10.1016/j.autrev.2009.08.001. Epub 2009 Aug 9.

B cell-targeted therapies in Sjögren's syndrome

Gabriel J Tobón  1 , Jacques Olivier Pers, Pierre Youinou, Alain Saraux
Affiliations
Review

B cell-targeted therapies in Sjögren's syndrome

Gabriel J Tobón et al. Autoimmun Rev. 2010 Feb.

Abstract

Sjögren's syndrome (SS) or autoimmune epithelitis is characterized by focal lymphocytic infiltrates surrounding the tubular epithelium of exocrine glands and by overactivity of the B-cell population. Although T cells were long considered the main effectors in SS, recent findings indicating a key role for B cells have prompted studies of treatments designed to deplete the B-cell population. Among molecules that can be targeted to achieve B-cell depletion, CD20 and CD22 are surface antigens expressed specifically by B lymphocytes; and the cytokine B-cell-activating factor belonging to the TNF family (BAFF) is a TNF receptor ligand involved in B-cell differentiation, survival, and activation. The aim of this review is to discuss the clinical outcomes of SS patients treated with B-cell depletion.

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