Calcium dysregulation in Alzheimer's disease: from mechanisms to therapeutic opportunities
- PMID: 19664678
- DOI: 10.1016/j.pneurobio.2009.07.009
Calcium dysregulation in Alzheimer's disease: from mechanisms to therapeutic opportunities
Abstract
Calcium is involved in many facets of neuronal physiology, including activity, growth and differentiation, synaptic plasticity, and learning and memory, as well as pathophysiology, including necrosis, apoptosis, and degeneration. Though disturbances in calcium homeostasis in cells from Alzheimer's disease (AD) patients have been observed for many years, much more attention was focused on amyloid-beta (Abeta) and tau as key causative factors for the disease. Nevertheless, increasing lines of evidence have recently reported that calcium dysregulation plays a central role in AD pathogenesis. Systemic calcium changes accompany almost the whole brain pathology process that is observed in AD, including synaptic dysfunction, mitochondrial dysfunction, presenilins mutation, Abeta production and Tau phosphorylation. Given the early and ubiquitous involvement of calcium dysregulation in AD pathogenesis, it logically presents a variety of potential therapeutic targets for AD prevention and treatment, such as calcium channels in the plasma membrane, calcium channels in the endoplasmic reticulum membrane, Abeta-formed calcium channels, calcium-related proteins. The review aims to provide an overview of the current understanding of the molecular mechanisms involved in calcium dysregulation in AD, and an insight on how to exploit calcium regulation as therapeutic opportunities in AD.
Similar articles
-
Calcium dysregulation in Alzheimer's disease.Neurochem Int. 2008 Mar-Apr;52(4-5):621-33. doi: 10.1016/j.neuint.2007.10.002. Epub 2007 Oct 5. Neurochem Int. 2008. PMID: 18035450 Review.
-
The role of Abeta-induced calcium dysregulation in the pathogenesis of Alzheimer's disease.J Alzheimers Dis. 2009;16(2):225-33. doi: 10.3233/JAD-2009-0951. J Alzheimers Dis. 2009. PMID: 19221414 Review.
-
Calcium dyshomeostasis and neurotoxicity of Alzheimer's beta-amyloid protein.Expert Rev Neurother. 2009 May;9(5):681-93. doi: 10.1586/ern.09.28. Expert Rev Neurother. 2009. PMID: 19402778 Review.
-
Presenilins as endoplasmic reticulum calcium leak channels and Alzheimer's disease pathogenesis.Sci China Life Sci. 2011 Aug;54(8):744-51. doi: 10.1007/s11427-011-4201-y. Epub 2011 Jul 24. Sci China Life Sci. 2011. PMID: 21786197 Review.
-
Linking calcium to Abeta and Alzheimer's disease.Neuron. 2008 Jul 31;59(2):190-4. doi: 10.1016/j.neuron.2008.07.013. Neuron. 2008. PMID: 18667147 Review.
Cited by
-
Single-molecule imaging reveals aβ42:aβ40 ratio-dependent oligomer growth on neuronal processes.Biophys J. 2013 Feb 19;104(4):894-903. doi: 10.1016/j.bpj.2012.12.051. Biophys J. 2013. PMID: 23442968 Free PMC article.
-
Effects of long-term memantine on memory and neuropathology in Ts65Dn mice, a model for Down syndrome.Behav Brain Res. 2011 Aug 10;221(2):610-22. doi: 10.1016/j.bbr.2010.03.036. Epub 2010 Apr 2. Behav Brain Res. 2011. PMID: 20363261 Free PMC article.
-
Alzheimer's Disease Puzzle: Delving into Pathogenesis Hypotheses.Aging Dis. 2024 Feb 1;15(1):43-73. doi: 10.14336/AD.2023.0608. Aging Dis. 2024. PMID: 37450931 Free PMC article. Review.
-
Alterations in synaptic plasticity coincide with deficits in spatial working memory in presymptomatic 3xTg-AD mice.Neurobiol Learn Mem. 2015 Nov;125:152-162. doi: 10.1016/j.nlm.2015.09.003. Epub 2015 Sep 15. Neurobiol Learn Mem. 2015. PMID: 26385257 Free PMC article.
-
Developmental and adult characterization of secretagogin expressing amacrine cells in zebrafish retina.PLoS One. 2017 Sep 26;12(9):e0185107. doi: 10.1371/journal.pone.0185107. eCollection 2017. PLoS One. 2017. PMID: 28949993 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
