Review
doi: 10.1016/0165-6147(90)90050-i.
Three-dimensional modelling of G protein-linked receptors
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- PMID: 1964255
- DOI: 10.1016/0165-6147(90)90050-i
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Review
Three-dimensional modelling of G protein-linked receptors
Trends Pharmacol Sci.
1990 Dec.
Erratum in
- Trends Pharmacol Sci 1991 Mar;12(3):81
Abstract
Members of the G protein-linked receptor superfamily have not yet yielded to X-ray crystallography. However, diffraction data from other membrane-bound receptors - the photosynthetic reaction centre and bacteriorhodopsin - have provided some information that may also apply to the G protein family. John Findlay and Elias Eliopoulos integrate this information together with analysis of amino acid sequences from cloned receptors, to derive workable three-dimensional models of these proteins. Such models identify ligand-binding and G protein-associating domains.
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