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Review
. 2009 Jul;7 Suppl 1(Suppl 1):28-30.
doi: 10.1111/j.1538-7836.2009.03423.x.

The fate of monocytes in atherosclerosis

G J Randolph  1
Affiliations
Review

The fate of monocytes in atherosclerosis

G J Randolph. J Thromb Haemost. 2009 Jul.

Abstract

Monocytes are the primary inflammatory cell type that infiltrates early atherosclerotic plaques. Their recruitment into plaques drives disease progression. Disease interventions that target monocytes could act at several points: alteration in the phenotype of circulating monocyte subpopulations; reduced recruitment of monocytes into plaques; alterations in the survival of monocyte-derived cells in atherosclerosis; and promotion of migratory egress from plaques to bring about resolution of the plaque inflammatory response. All of these points of intervention will be briefly discussed in this article.

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Conflict of interest statement

Disclosure of Conflict of Interests

The authors state that they have no conflict of interests.

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