Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2009 Jul;17(1):6-8.
doi: 10.1016/j.devcel.2009.07.004.

TGF-beta: a new role for an old AktTOR

Pankuri Goraksha-Hicks  1 , Jeffrey C Rathmell
Affiliations
Comment

TGF-beta: a new role for an old AktTOR

Pankuri Goraksha-Hicks et al. Dev Cell. 2009 Jul.

Abstract

Nutrient overabundance is known to promote cellular hypertrophy, a significant pathological event in diseases like diabetes and cancer, although mechanisms have remained unclear. In this issue of Developmental Cell, Wu and Derynck provide a new model that links metabolism and cell growth by demonstrating that hyperglycemia can increase TGF-beta-dependent activation of the mTOR pathway to promote cellular hyperplasia.

PubMed Disclaimer

Figures

Figure 1
Figure 1. Model of Glucose-Stimulated Cellular Hypertrophy
Hyperglycemia increases TGF-β signaling through two proposed mechanisms (red dashed arrows). Glucose overabundance led to increased cell surface levels of TβRI and RII as well as activation and processing of latent TGF-β by MMP-2 and MMP-9. Cellular hypertrophy is caused by Smad-independent activation of the PI3K/Akt/mTOR pathway.
See this image and copyright information in PMC

Comment on

Similar articles

See all similar articles

Cited by

References

    1. Conlon I, Raff M. Cell. 1999;96:235–244. - PubMed
    1. Lamouille S, Derynck R. J Cell Biol. 2007;178:437–451. - PMC - PubMed
    1. Plas DR, Thompson CB. Oncogene. 2005;24:7435–7442. - PubMed
    1. Rahimi RA, Leof EB. J Cell Biochem. 2007;102:593–608. - PubMed
    1. Rathmell JC, Vander Heiden MG, Harris MH, Frauwirth KA, Thompson CB. Mol Cell. 2000;6:683–692. - PubMed

MeSH terms

Substances