Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comparative Study
. 1991 Dec 1;88(23):10642-6.
doi: 10.1073/pnas.88.23.10642.

Expression of GATA-binding proteins during embryonic development in Xenopus laevis

L I Zon  1 , C Mather, S Burgess, M E Bolce, R M Harland, S H Orkin
Affiliations
Comparative Study

Expression of GATA-binding proteins during embryonic development in Xenopus laevis

L I Zon et al. Proc Natl Acad Sci U S A. .

Abstract

Proteins that recognize the core sequence GATA are important regulators of hematopoietic-specific gene transcription. We have characterized cDNAs encoding the Xenopus laevis homologues of three related transcription factors, designated GATA-1, -2, and -3. Comparative sequence analysis reveals strong conservation of the zinc-finger DNA-binding domain among all vertebrate GATA-binding proteins. GATA-2 and GATA-3 polypeptides are homologous throughout their entire sequences, whereas GATA-1 sequence is conserved only in the region responsible for DNA binding. In Xenopus, RNAs encoding GATA-binding proteins are expressed in both larval and adult erythroid cells. GATA-1, -2, and -3 RNAs are first detectable in early gastrula (Nieuwkoop developmental stage 11). This is earlier than the appearance of the early larval alpha T1 globin RNA (stage 15), beta T1 globin RNA (stage 26), or blood island formation (stage 30). The expression of GATA-1, -2, and -3 in early development may signal an early commitment of mesoderm to form hematopoietic tissue.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Nature. 1990 Sep 13;347(6289):197-200 - PubMed
    1. Nature. 1990 Jun 21;345(6277):729-31 - PubMed
    1. Cell. 1990 Nov 16;63(4):665-72 - PubMed
    1. Mol Cell Biol. 1990 Dec;10(12):6596-606 - PubMed
    1. Genes Dev. 1990 Oct;4(10):1650-62 - PubMed

Publication types

MeSH terms

LinkOut - more resources