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. 2009 Aug 15;8(16):2662-3.
doi: 10.4161/cc.8.16.9329. Epub 2009 Aug 22.

The sirtuin SIRT6 deacetylates H3 K56Ac in vivo to promote genomic stability

Bo Yang, Bernadette M M Zwaans, Mark Eckersdorff, David B Lombard

The sirtuin SIRT6 deacetylates H3 K56Ac in vivo to promote genomic stability

Bo Yang et al. Cell Cycle. .
No abstract available

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Figures

Fig. 1
Fig. 1
SIRT6 deacetylates H3 K56Ac. (A) Hyperacetylation of H3 K56Ac in the absence of SIRT6. (Left panel) Hyperacetylation of H3 K56Ac in SIRT6-deficient MEFs. (Middle panel) Hyperacetylation of H3 K56Ac in SIRT6-deficient ES cells. (Right panel) Reconstitution of a SIRT6-deficient fibroblast cell line with catalytically active SIRT6 reduces H3 K56Ac levels. (B) Immunofluorescence analysis of SIRT6-deficient MEFs and littermate controls. (C) Hyperacetylation of H3 K56Ac in thymus (top panels) and brain (bottom panels) of a SIRT6-deficient mouse and littermate control. (D) Recombinant SIRT6 deacetylates H3 K56Ac in vitro.
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