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Review
. 1991:40:181-211.
doi: 10.1016/s0065-3527(08)60279-1.

Effects of defective interfering viruses on virus replication and pathogenesis in vitro and in vivo

L Roux  1 , A E Simon, J J Holland
Affiliations
Review

Effects of defective interfering viruses on virus replication and pathogenesis in vitro and in vivo

L Roux et al. Adv Virus Res. 1991.

Abstract

DI viruses and defective viruses generally are widespread in nature. Laboratory studies show that they can sometimes exert powerful disease-modulating effects (either attenuation or intensification of symptoms). Their role in nature remains largely unexplored, despite recent suggestive evidence for their importance in a number of systems.

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