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. 2009 Jul;18(7):2137-44.
doi: 10.1158/1055-9965.EPI-08-1223. Epub 2009 Jun 30.

Genetic variants and prostate cancer risk: candidate replication and exploration of viral restriction genes

Joan P Breyer  1 , Kate M McReynolds, Brian L Yaspan, Kevin M Bradley, William D Dupont, Jeffrey R Smith
Affiliations

Genetic variants and prostate cancer risk: candidate replication and exploration of viral restriction genes

Joan P Breyer et al. Cancer Epidemiol Biomarkers Prev. 2009 Jul.

Abstract

The genetic variants underlying the strong heritable component of prostate cancer remain largely unknown. Genome-wide association studies of prostate cancer have yielded several variants that have significantly replicated across studies, predominantly in cases unselected for family history of prostate cancer. Additional candidate gene variants have also been proposed, many evaluated within familial prostate cancer study populations. Such variants hold great potential value for risk stratification, particularly for early-onset or aggressive prostate cancer, given the comorbidities associated with current therapies. Here, we investigate a Caucasian study population of 523 independent familial prostate cancer cases and 523 age-matched controls without a personal or family history of prostate cancer. We replicate identified associations at genome-wide association study loci 8q24, 11q13, and 2p15 (P = 2.9 x 10(-4) to P = 4.7 x 10(-5)), showing study population power. We also find evidence to support reported associations at candidate genes RNASEL, EZH2, and NKX3-1 (P = 0.031 to P = 0.0085). We further explore a set of candidate genes related to RNASEL and to its role in retroviral restriction, identifying nominal associations at XPR1 and RBM9. The effects at 8q24 seem more pronounced for those diagnosed at an early age, whereas at 2p15 and RNASEL the effects were more pronounced at a later age. However, these trends did not reach statistical significance. The effects at 2p15 were statistically significantly more pronounced for those diagnosed with aggressive disease.

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Figures

Figure 1
Figure 1
Haplotype association with prostate cancer. To left: Sliding haplotype windows of P ≤ 0.05 by χ2 analysis, graphically ordered as most to least significant (from black to grey). To right: Logistic regression analysis for haplotypes designated in black (number of subjects 1,046). Among all genes of the study, only RNASEL, XPR1, and RBM9, yielded haplotype windows of P ≤ 0.05. The open boxed haplotype window of XPR1 is common to both protective haplotypes.
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