doi: 10.1002/biot.200800357.
Involvement of cellular proteins in Junin arenavirus entry
Affiliations
- PMID: 19548229
- DOI: 10.1002/biot.200800357
Item in Clipboard
Involvement of cellular proteins in Junin arenavirus entry
Biotechnol J.
2009 Jun.
Abstract
Junin arenavirus (JUNV) entry is dependent on clathrin-mediated pathways and it relies on the integrity of the actin cytoskeleton as well as the dynamics of microtubules. To determine the method of entry used by this human pathogen, we have demonstrated that in Vero cells JUNV is trafficked via the cellular dynamin 2 (dyn2) endocytic pathway and it is dependent on the Eps15 GTPase. In addition, we have shown that the virus travels through Rab5-mediated early and Rab7-mediated late endosomes in its pH-dependent entry. Altogether, this study gives further inside into the endocytic pathway utilized by the arenavirus JUNV.
Similar articles
-
Pichindé virus is trafficked through a dynamin 2 endocytic pathway that is dependent on cellular Rab5- and Rab7-mediated endosomes.Arch Virol. 2008;153(7):1391-6. doi: 10.1007/s00705-008-0129-3. Epub 2008 Jun 10. Arch Virol. 2008. PMID: 18543061
-
Involvement of cytoskeleton in Junín virus entry.Virus Res. 2008 Dec;138(1-2):17-25. doi: 10.1016/j.virusres.2008.08.004. Epub 2008 Sep 30. Virus Res. 2008. PMID: 18789362
-
Entry of Classical Swine Fever Virus into PK-15 Cells via a pH-, Dynamin-, and Cholesterol-Dependent, Clathrin-Mediated Endocytic Pathway That Requires Rab5 and Rab7.J Virol. 2016 Sep 29;90(20):9194-208. doi: 10.1128/JVI.00688-16. Print 2016 Oct 15. J Virol. 2016. PMID: 27489278 Free PMC article.
-
Rab5 and Rab11 Are Required for Clathrin-Dependent Endocytosis of Japanese Encephalitis Virus in BHK-21 Cells.J Virol. 2017 Sep 12;91(19):e01113-17. doi: 10.1128/JVI.01113-17. Print 2017 Oct 1. J Virol. 2017. PMID: 28724764 Free PMC article.
-
Characterization of Junin arenavirus cell entry.J Gen Virol. 2007 Jun;88(Pt 6):1776-1784. doi: 10.1099/vir.0.82808-0. J Gen Virol. 2007. PMID: 17485539
Cited by
-
Host cell factors as antiviral targets in arenavirus infection.Viruses. 2012 Sep;4(9):1569-91. doi: 10.3390/v4091569. Epub 2012 Sep 13. Viruses. 2012. PMID: 23170173 Free PMC article. Review.
-
IFITMs restrict the replication of multiple pathogenic viruses.J Mol Biol. 2013 Dec 13;425(24):4937-55. doi: 10.1016/j.jmb.2013.09.024. Epub 2013 Sep 25. J Mol Biol. 2013. PMID: 24076421 Free PMC article. Review.
-
Cell Walls and the Convergent Evolution of the Viral Envelope.Microbiol Mol Biol Rev. 2015 Dec;79(4):403-18. doi: 10.1128/MMBR.00017-15. Microbiol Mol Biol Rev. 2015. PMID: 26378223 Free PMC article. Review.
-
Identification and Characterization of a Novel Broad-Spectrum Virus Entry Inhibitor.J Virol. 2016 Apr 14;90(9):4494-4510. doi: 10.1128/JVI.00103-16. Print 2016 May. J Virol. 2016. PMID: 26912630 Free PMC article.
-
Junin Virus Activates p38 MAPK and HSP27 Upon Entry.Front Cell Infect Microbiol. 2022 Apr 7;12:798978. doi: 10.3389/fcimb.2022.798978. eCollection 2022. Front Cell Infect Microbiol. 2022. PMID: 35463647 Free PMC article.
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Miscellaneous
