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Review
. 2009 Jul;9(7):491-502.
doi: 10.1038/nri2572.

Cracking the BAFF code

Fabienne Mackay  1 , Pascal Schneider
Affiliations
Free article
Review

Cracking the BAFF code

Fabienne Mackay et al. Nat Rev Immunol. 2009 Jul.
Free article

Abstract

The tumour necrosis factor (TNF) family members B cell activating factor (BAFF) and APRIL (a proliferation-inducing ligand) are crucial survival factors for peripheral B cells. An excess of BAFF leads to the development of autoimmune disorders in animal models, and high levels of BAFF have been detected in the serum of patients with various autoimmune conditions. In this Review, we consider the possibility that in mice autoimmunity induced by BAFF is linked to T cell-independent B cell activation rather than to a severe breakdown of B cell tolerance. We also outline the mechanisms of BAFF signalling, the impact of ligand oligomerization on receptor activation and the progress of BAFF-depleting agents in the clinical setting.

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