doi: 10.1093/jnci/59.1.165.
Herpesvirus saimiri-induced lymphoproliferative disease in howler monkeys
- PMID: 195067
- DOI: 10.1093/jnci/59.1.165
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Herpesvirus saimiri-induced lymphoproliferative disease in howler monkeys
J Natl Cancer Inst.
1977 Jul.
Abstract
Four of 5 howler monkeys (Alouatta caraya) experimentally infected with Herpesvirus saimiri (HVS) developed a rapidly fatal malignant lymphoma accompanied by peripheral T-cell lymphocytosis. HVS was isolated from fresh and tissue cultured blood and tissue lymphocytes and from cell cultures derived from nonlymphoid organs. Humoral antibodies against HVS-induced antigens were detected in the sera of the animals. The in vitro response of the peripheral blood lymphocytes to mitogenic stimulants was depressed following HVS infection.
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